摘要
稳定的肠道微生物内环境是肠道微生物与肠道免疫反应相互作用的结果。在不断的进食过程中,昆虫肠道微生物种类和数量不断发生变化,肠道微生物与肠道上皮细胞之间形成了复杂的、动态的平衡机制。昆虫肠道上皮细胞可以感知有益和有害条件并利用免疫调控通路来实现微生物种群稳态的动态调节,例如双重氧化酶-活性氧(dual oxidase-reactive oxygen species,Duox-ROS)系统和免疫缺陷(immunodeficiency,Imd)信号通路可以感知肠道微生物数量变化并参与到肠道微生物稳态调节过程。除此之外,肠道微生物群也会通过群体感应(quorum sensing,QS)释放相应的效应因子来调节菌群行为,间接性起到稳态调节的作用。因此,本文综述了昆虫肠道中物理防御、免疫信号通路以及肠道微生物通过QS在昆虫肠道微生物稳态维持中的作用,加深对肠道组织与肠道微生物互作关系的认识。未来将继续对更多种类昆虫体内微生物的稳态调控机制及调控机制间的作用关系进行研究,并基于调控机制设计开发改变肠道微生物稳态的新型农药,为实现有效害虫防治提供新的靶标和思路。
A stable intestinal microbial internal environment is the result of the interaction between intestinal microbes and intestinal immune response.During the continuous feeding,the species and number of insect intestinal microbes constantly change,so a complex and dynamic homeostatic mechanism is formed between intestinal microbes and intestinal epithelial cells.Insect intestinal epithelial cells can sense beneficial and harmful conditions and use immunoregulatory pathways for dynamic regulation of microbial population homeostasis,such as the dual oxidase-reactive oxygen species(Duox-ROS)system and immunodeficiency(Imd)signaling pathways,which can sense the changes in the number of intestinal microbies and participate in the regulation of intestinal microbial homeostasis.In addition,the intestinal microbes can also indirectly play a role in homeostatic regulation by releasing corresponding effectors to regulate the behavior of the flora through quorum sensing(QS).Thus,in this article,we reviewed the roles of physical defense,immune signaling pathways and QS in the maintenance of insect intestinal microbial homeostasis,which will deepen the understanding of the interactions between intestinal tissues and intestinal microbes.In the future,we will continue to reveal the regulatory mechanisms of microbial homeostasis in more species of insects and the relationship between the regulatory mechanisms.In addition,new pesticides will be designed and developed to alter the homeostasis of intestinal microbes based on the regulatory mechanisms,which will provide new targets and ideas for the pest control.
作者
宋阳
范琳琳
申屠旭萍
俞晓平
SONG Yang;FAN Lin-Lin;SHENTU Xu-Ping;YU Xiao-Ping(Zhejiang Key Laboratory of Biometrics,Inspection and Quarantine Technology,College of Life Sciences,China Jiliang University,Hangzhou 310018,China)
出处
《昆虫学报》
CAS
CSCD
北大核心
2023年第10期1404-1414,共11页
Acta Entomologica Sinica
基金
浙江省重点研发计划项目(2021C02061,2023C02030,2019C02015,2017C32006)
浙江省属高校基本科研业务费(2022YW17)
国家重点研发计划项目(2022YFF0608402)
浙江省“三农九方”科技协作计划(2023SNJF034)
国家自然科学基金区域联合基金(U21A20223)
浙江省“领雁”研发攻关计划项目(2023C02030,2022C02047)。
