摘要
目的 血小板-内皮细胞粘附分子-1(platelet endothelial cell adhesion molecule-1,PECAM-1)、胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、可溶性骨髓细胞样转录因子-1(soluble bone marrow cell-like transcription factor-1,sTLT-1)在急性脑梗死(acute cerebral infarction,ACI)患者中的表达及相关性研究。方法 选取2019年5月-2020年10月我院收治的ACI患者77例作为实验组,按照神经功能缺损评分量表(national institute of health stroke scale,NIHSS)评分分为轻度患者36例,中度患者25例,重度患者16例;根据磁共振成像(magnetic resonance imaging,MRI)反应的梗死面积将患者分为小面积梗死灶(small area of infarction,SI)38例、中度面积梗死灶(moderate area of infarct,MI)26例以及大面积梗死灶(large area of infarction,LI)13例,同时选取在我院同一时间点进行健康体检的健康人员77例作为正常组,采用酶联免疫吸附法检测PECAM-1、GFAP、sTLT-1水平。结果 与正常组相比,实验组PECAM-1、GFAP、sTLT-1显著升高,具有统计学差异(P<0.05);与轻度组相比,中度组和重度组水平升高,与中度组相比,重度组水平显著升高,具有统计学差异(P<0.05);与SI相比,Ml和LI水平升高,与MI相比,LI水平显著升高,具有统计学差异(P<0.05)。结论 PECAM-1、GFAP、sTLT-1在ACI患者血清中表现异常,与患者的严重程度、梗死面积有密切关系,可能参与ACI的发生发展,提示PECAM-1、GFAP、sTLT-1在ACI的临床诊断中具有一定作用。
Objective Platelet endothelial cell adhesion molecule-1(PECAM-1),glial fibrillary acidic protein(GFAP),soluble bone marrow cell-like transcription factor-1(sTLT-1)in acute cerebral infarction(ACI)The expression and its correlation in patients with ACI.Methods 77 patients with ACI admitted to our hospital from May 2019 to October 2020 were selected as the experimental group.According to the National Institute of Health Stroke Scale(NI HSS)score,they were divided into 36 mild patients,25 moderate patients and 16 severe patients The patients were divided into small area of infarction(SI)in 38 cases,moderate area of infarct(MI)in 26 cases and large area of infarction(LI)in 13 cases,At the same time,77 healthy people who had physical examination in our hospital at the same time point were selected as the normal group.The levels of PECAM-1,GFAP and sTLT-1 were detected by enzyme-linked immunosorbent assay.Results Compared with the normal group,PECAM-1,GFAP,sTLT-1 in the experimental group were significantly increased,with statistical difference(P<0.05);compared with the mild group,the levels of PECAM-1,GFAP and sTLT-1 in the experimental group were significantly increased,with statistical difference(P<0.05);compared with SI,the levels of MI and LI were increased,and the level of LI was significantly increased,with statistical difference(P<0.05).Conclusion PECAM-1,GFAP and sTLT-1 are abnormal in serum of ACI patients,which are closely related to the severity and infarct size of patients,and may be involved in the occurrence and development of ACI.have a role in diagnosis.
作者
袁亚春
Yuan Ya-chun(Clinical Laboratory,Changzhou Xinbei District Chunjiang People's Hospital,Changzhou 213014,Jiangsu Province,China)
出处
《罕少疾病杂志》
2023年第11期20-22,共3页
Journal of Rare and Uncommon Diseases
关键词
血小板-内皮细胞粘附分子-1
胶质纤维酸性蛋白
可溶性骨髓细胞样转录因子-1
急性脑梗死
Platelet Endothelial Cell Adhesion Molecule-1
Glial Fibrillary Acidic Protein
Soluble Bone Marrow Cell Like Transcription Factor-1
Acute Cerebral Infarction
