摘要
糖尿病伤口是糖尿病的常见并发症,具有发病机制复杂、伤口易感染难愈合等特点。为了清除感染、缓解伤口炎症和防止坏死,多种功能性水凝胶被成功研制并作为伤口敷料用于消除病原体感染,根据功能不同,水凝胶可分为抗菌水凝胶、抗炎水凝胶及多功能水凝胶。其中,根据作用原理不同,抗菌水凝胶又包括固有抗菌水凝胶、负载抗菌剂水凝胶及触发式抗菌水凝胶。水凝胶在糖尿病伤口的治疗取得了一定的进展,但其仍然存在如成本过高、吸水性不足等问题,有待进一步完善。该文系统总结了功能性水凝胶应用于糖尿病伤口的研究进展,可为糖尿病伤口的临床治疗提供新思路。
Diabetic wounds are common complications of diabetes,characterized by complex pathogenesis,susceptibility to infection,and difficulty in healing.To eliminate pathogenic infections,alleviate wound inflammation,and prevent necrosis,various functional hydrogels have been successfully developed as wound dressings.Based on their different functions,hydrogels can be categorized into antibacterial ones,anti-inflammatory ones,and multifunctional ones.Among them,antibacterial hydrogels can be further divided into intrinsic antibacterial ones,drug-loaded antibacterial ones,and triggerable antibacterial ones,depending on their mechanisms of action.While hydrogels have made progress in the treatment of diabetic wounds,there are still some to-be-improved issues such as high cost,and insufficient water absorption.This article systematically summarizes the research progress of functional hydrogels applied to diabetic wounds,aiming to provide new ideas for the clinical treatment of diabetic wounds.
作者
马俊杰
刘晨光
MA Junjie;LIU Chenguang(College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China)
出处
《浙江理工大学学报（自然科学版）》
2023年第6期795-802,共8页
Journal of Zhejiang Sci-Tech University(Natural Sciences)
基金
国家自然科学基金项目(32201092)。
关键词
糖尿病伤口
伤口敷料
水凝胶
抗菌水凝胶
抗炎水凝胶
多功能水凝胶
diabetic wound
wound dressing
hydrogels
antibacterial hydrogel
anti-inflammatory hydrogel
multifunctional hydrogel
