摘要
目的探讨脑梗死后血清β2微球蛋白(β2-microglobulin,β2-MG)、胱抑素-C(Cystatin-C,Cys-C)水平与抑郁的关系。方法本研究纳入2021年2月~2023年2月97例脑梗死患者为研究对象,脑梗死后进行早期抑郁筛查,并根据筛查结果划分为抑郁组以及非抑郁组。比较两组患者一般病历资料以及血清β2-MG、Cys-C水平,通过二元Logistic回归分析β2-MG、Cys-C与抑郁的关系。结果97例患者中合并抑郁28例;抑郁组年龄、学历、巴塞尔指数(Barthel index,BI)、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)与非抑郁组差异显著(P<0.05),两组居住地、性别、婚姻差异无统计学意义(P>0.05);抑郁组血清β2-MG、Cys-C水平显著高于非抑郁组,(P<0.05);二元Logistic回归分析显示小学学历、BI指数、NIHSS评分、血清β2-MG、Cys-C水平是脑梗死后早期抑郁的影响因素(P<0.05)。结论脑梗死后抑郁发生率较高,血清β2-MG、Cys-C水平与抑郁严重程度具有正相关关系,可能促进抑郁的发生与发展。
Objective To investigate the relationship between serumβ2-microglobulin(β2-MG)and cystatin-C(Cys-C)levels and depression after cerebral infarction.Methods Ninety-seven patients with cerebral infarction from February 2021 to February 2023 were included in this study.Depression screening was performed after cerebral infarction,and they were divided into depressed as well as non-depressed groups based on the screening results.The general medical history data and serumβ2-MG and Cys-C levels were compared between the two groups.The relationship betweenβ2-MG,Cys-C and depression was analyzed by binary logistic regression.Results There were 28 cases of combined depression among 97 patients;age,education,Barthel index(BI),and the National Institutes of Health Stroke Scale(NIHSS)in the depressed group differed significantly(P<0.05)from those in the nondepressed group.There was no statistically significant difference between the two groups in terms of place of residence,gender and marriage(P>0.05).Serumβ2-MG and Cys-C levels were significantly higher in the depressed group than in the non-depressed group(P<0.05).Binary logistic regression analysis showed that elementary school literacy level,BI index,NIHSS score,serumβ2-MG,and Cys-C levels were influential factors for depression after cerebral infarction(P<0.05).Conclusion The incidence of depression is higher in the early post-infarction period,and Serum levels ofβ2-MG and Cys-C are positively correlated with the severity of depression,which may promote the occurrence and development of depression.
作者
李波
邓静静
李文涛
王婵
王胜
LI Bo;DENG Jingjing;LI Wentao(Neurology,Jiaozuo Second People's Hospital,Jiaozuo 454000,China)
出处
《国际精神病学杂志》
2023年第5期1058-1060,共3页
Journal Of International Psychiatry
关键词
脑梗死
抑郁
Β2微球蛋白
胱抑素-C
Cerebral Infarction
Depression
β2 Microglobulin
Cystatin-C
