摘要
细胞焦亡是一种由Gasdermin家族蛋白介导的新型程序性细胞死亡。当宿主细胞感应病原体感染或其他危险信号时,Gasdermin家族蛋白被切割活化并诱导细胞焦亡。细胞焦亡过程往往伴随大量炎性细胞因子释放,这些炎性细胞因子在宿主清除病原体过程中发挥着至关重要作用,而病原体在与宿主长期“博弈”过程中也进化出抑制细胞焦亡的策略以实现免疫逃逸。本文介绍了细胞焦亡的发现历程及其在抗感染免疫中的重要功能,并总结了病原体抑制细胞焦亡的多种新策略及其相关研究进展。深入理解细胞焦亡的发生及调控机制,可揭示相关感染性疾病的发病机制并有助于开发有效的抗感染治疗策略。
Pyroptosis is a type of programmed cell death mediated by the Gasdermin family.It is triggered in response to pathogen infection or other danger signals.The activation of Gasdermins leads to pyroptosis and the release of large amounts of inflammatory cytokines.Pyroptosis plays a crucial role in combating pathogen infections,as it helps to eliminate infected cells and activate the immune system.However,pathogens have already developed sophisticated strategies to evade or inhibit pyroptosis,allowing them to persist and facilitate infection.This review provides an overview of the discovery of pyroptosis and its importance in anti-infectious immunity.We also discuss several new strategies for inhibiting pyroptosis by pathogens.A thorough learning of the occurrence and regulation of pyroptosis may reveal the pathogenesis of related infectious diseases and contribute to developing effective anti-infective therapeutic strategies.
作者
杨茂艺
崔潇月
郑诗棋
马诗瑶
郑增长
邓万燕
Maoyi Yang;Xiaoyue Cui;Shiqi Zheng;Shiyao Ma;Zengzhang Zheng;Wanyan Deng(Key Laboratory of Molecular Biology on Infectious Disease,Ministry of Education,Chongqing Medical University,Chongqing 400010,China;Department of Pathogenic Biology,College of Basic Medicine,Chongqing Medical University,Chongqing 400010,China;Department of Basic Laboratory,Suining Central Hospital,Suining 629000,China;Shanghai East Hospital,Tongji University,Shanghai 200120,China)
出处
《遗传》
CAS
CSCD
北大核心
2023年第11期986-997,共12页
Hereditas（Beijing)
基金
重庆市自然科学基金创新发展联合基金(编号:CSTB2022NSCQ-LZX0031)资助。
