摘要
目的评价血管内超声(IVUS)指导药物涂层球囊(DCB)介入治疗冠心病患者原位冠状动脉病变的临床效果。方法选择2022年2月至2022年12月在江南大学附属医院接受冠状动脉造影(CAG)检查及DCB治疗的64例冠心病患者,根据IVUS检查结果分为大血管组(n=40,血管直径≥2.75 mm)和小血管组(n=24,血管直径<2.75 mm)。比较两组患者DCB治疗前后IVUS检测指标,术后10个月晚期管腔丢失(LLL)、主要心血管不良事件(MACE)。结果两组患者基线资料比较差异无统计学意义(均P>0.05)。大血管组、小血管组DCB术后即刻最小管腔直径分别为(3.60±0.89)mm、(3.09±0.72)mm,差异无统计学意义(P>0.05);大血管组DCB术后即刻最小管腔面积、最小管腔直径大于术前,斑块负荷明显低于术前(均P<0.05)。随访10个月CAG复查时,大血管组、小血管组LLL分别为(0.15±0.08)mm、(0.12±0.04)mm,差异无统计学意义(P=0.27);均无MACE发生。结论IVUS指导和充分预处理后DCB介入治疗原位冠状动脉大血管病变安全有效。
Objective To evaluate the clinical efficacy of intravascular ultrasound-guided(IVUS-guided)interventional drug-coated balloon(DCB)treatment for the coronary arterial lesion in situ.Methods A total of 64 patients with coronary heart disease,who were admitted to the Affiliated Hospital of Jiangnan University of China between February 2022 and December 2022 to receive coronary angiography(CAG)and DCB treatment,were enrolled in this study.According to the IVUS examination results,the patients were divided into large vessel group(n=40,vessel diameter≥2.75 mm)and small vessel group(n=24,vessel diameter<2.75 mm).The preoperative and postoperative detection indexes of IVUS,the postoperative 10-month late lumen loss(LLL)and major adverse cardiovascular events(MACE)were compared between the two groups.Results There were no significant differences in baseline data between the two groups(all P>0.05).The minimum lumen diameter measured immediately after DCB treatment in the large vessel group and the small vessel group were(3.60±0.89)mm and(3.09±0.72)mm respectively,the difference was not statistically significant(P>0.05).In the large vessel group,immediately after DCB the lumen area and minimum lumen diameter were larger than their preoperative values,while the plaque load was significantly lower than preoperative value(all P<0.05).Follow-up examination with CAG at 10 months after treatment showed that the LLL in the large vessel group and the small vessel group was(0.15±0.08)mm and(0.12±0.04)mm respectively,the difference between the two groups was not statistically significant(P=0.27).No MACE occurred in both groups.Conclusion With IVUS guidance and adequate pretreatment,DCB treatment is clinically safe and effective for large coronary vessel lesion in situ.
作者
刘洁银
鲍骏
苏衡
施晶晶
尚晖
蔡文渊
王锡惠
过云峰
高长征
陈翀昊
李云飞
吴学明
王广艳
顾鑫
王晓彦
LIU Jieyin;BAO Jun;SU Heng;SHI Jingjing;SHANG Hui;CAI Wenyuan;WANG Xihui;GUO Yunfeng;GAO Changzheng;CHEN Chonghao;LI Yunfei;WU Xueming;WANG Guangyan;GU Xin;WANG Xiaoyan(Department of Cardiovascular Medicine,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu Province 214122,China)
出处
《介入放射学杂志》
CSCD
北大核心
2023年第10期960-964,共5页
Journal of Interventional Radiology
基金
江苏省卫生健康委医学科研重大项目(ZDA2020023)
无锡市卫生计生委面上项目(MS201514)
无锡市科技局面上项目(N20202019)
无锡市卫生健康委精准医学专项项目(J202103)。
关键词
血管内超声
药物涂层支架
原位冠状动脉病变
intravascular ultrasound
drug-coated balloon
coronary arterial lesion in situ
