摘要
目的分析妊娠期肝内胆汁淤积症(ICP)的影响因素,并探讨其对妊娠结局产生的影响。方法选取58例ICP孕妇为研究组,另选取同期58例健康孕妇为对照组,回顾性分析ICP发生的影响因素及其对妊娠结局的影响。结果单因素分析中,研究组有ICP病史或家族史、乙肝或其他肝胆疾病、合并高血压、合并糖尿病和多胎妊娠的发生率高于对照组(P<0.05);研究组肝功能各项指标水平均高于对照组(P<0.05);研究组早产、宫内窘迫、低体重儿、羊水污染和窒息发生率均高于对照组(P<0.05);多因素Logistic回归分析结果显示,合并高血压、合并糖尿病、多胎妊娠和高总胆汁酸是诱发ICP发生的独立危险因素(P<0.05)。结论ICP会使孕妇出现多种不良妊娠结局,其中合并高血压、合并糖尿病、多胎妊娠、高总胆汁酸是其危险因素。
Objective To analyze the influential factors of intrahepatic cholestasis of pregnancy(ICP)and to explore its influence on pregnancy outcome.Methods A total of 58 pregnant women with ICP were selected as the study group and 58 healthy pregnant women were selected as the control group.The influencing factors of ICP and its influence on pregnancy outcome were analyzed retrospectively.Results In the single risk factor analysis,the incidence of ICP or family history,hepatitis B or other liver and gallbladder diseases,hypertension,diabetes and multiple pregnancy in the study group was higher than that in the control group(P<0.05).The levels of liver function indexes in the study group were higher than those in the control group(P<0.05).The incidence of premature birth,intrauterine distress,low birth weight infants,amniotic fluid contamination and asphyxia in the study group were higher than those in the control group(P<0.05).Multiple risk factor Logistic regression analysis showed that hypertension,diabetes,multiple pregnancy and high total bile acid were independent risk factors for ICP(P<0.05).Conclusion ICP can cause a variety of adverse pregnancy outcomes in pregnant women,among which hypertension,diabetes,multiple pregnancy and high total bile acid are risk factors.
作者
梁映颖
蓝继常
周玉秀
Liang Yingying;Lan Jichang;Zhou Yuxiu(Department of Obstetrics,Liuzhou Hospital of Traditional Chinese Medicine,Liuzhou Zhuang Medical Hospital,Liuzhou 545000,China)
出处
《实用妇科内分泌电子杂志》
2023年第18期15-18,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
妊娠结局
妊娠期肝内胆汁淤积症
影响因素
Pregnancy outcome
Intrahepatic cholestasis of pregnancy
Influencing factor
