摘要
阿尔茨海默病是一个连续疾病谱,由主观认知下降—轻度认知障碍—阿尔茨海默病逐渐进展,其中医证候存在一定的演变规律。“肾藏精,精舍志”,肾虚为痴呆的始动因素。通过梳理阿尔茨海默病各阶段的证候研究文献,发现肾虚证为阿尔茨海默病最基本的证候,且贯穿于疾病始终。主观认知下降期以肾虚证为主;轻度认知障碍期仍以肾虚为主,但分布频率较前下降,兼夹痰浊、瘀血、气血亏虚等;阿尔茨海默病期证候类型复杂,早期大致同轻度认知障碍期,中期以痰浊和血瘀为主,晚期以毒盛和虚极为主。该结果为临床分期施治阿尔茨海默病提供了理论依据。
Alzheimer's disease(AD)is a continuous disease spectrum that gradually progresses from subjective cognitive decline(SCD)to mild cognitive impairment(MCI)and finally to Alzheimer's Disease(AD),and its TCM syndromes feature certain evolution patterns.As the kidney stores essence and the essence sheds will,kidney deficiency is the initiating factor for dementia.This paper combs the research literature of syndromes in various stages of AD,and finds that kidney deficiency is its most basic syndrome,and runs through its entire course.The stage of SCD is mainly characterized by a kidney deficiency syndrome,while the stage of MCI is still characterized by a kidney deficiency syndrome,but its distribution frequency is lower than before,combined with phlegm turbidity,blood stasis,qi and blood deficiency,etc.,and the AD stage bears a complex syndrome,with its early stage roughly the same as the MCI,its middle stage dominated by phlegm turbidity and blood stasis,and its late stage dominated by excessive toxicity and deficiency.The study result is supposed to provide a theoretical basis for the clinical treatment of AD by stages.
作者
张梦雪
曲彦洁
安红梅
ZHANG Mengxue;QU Yanjie;AN Hongmei(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Traditional Chinese Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200001,China)
出处
《吉林中医药》
2023年第11期1361-1364,共4页
Jilin Journal of Chinese Medicine
基金
上海市科委医学创新研究项目(21Y11920900)
龙华医院科技创新项目(CX202052)
上海市医院中药制剂产业转化协同创新中心项目(2093)。
关键词
阿尔茨海默病
认知分级
肾虚证
动态演变
Alzheimer's disease
cognitive level
kidney deficiency syndrome
dynamic evolution
