摘要
目的 观察调脉合剂对阵发性心房颤动合并稳定性冠心病气阴两虚证患者心率变异性及房颤负荷的影响。方法 采用随机平行对照临床试验,将56例阵发性心房颤动合并稳定性冠心病证属气阴两虚证的患者,随机分组,治疗组30例,对照组26例,2组患者均予常规基础治疗,在此基础上,治疗组患者联合调脉合剂,2组患者均连续治疗4周。对比2组患者心率变异性、房颤负荷及中医证候疗效指标。结果 经治疗后,2组患者记录全程NN间期的标准差(standard deviation of N-N intervals, SDNN),相邻NN间期之差的均方根(mean square of successive differences,RMSSD),高频率范围内NN间期变异(high frequency, HF)均非常明显升高(P<0.01),组间比较差异有统计学意义(P<0.01)。LF/HF,房颤负荷均非常明显降低,组间比较差异具有统计学意义(P<0.05);中医证候疗效方面,治疗组总有效率90.0%,对照组总有效率61.5%,治疗组中医症状改善方面,明显优于对照组(P<0.05)。结论 调脉合剂可以提高阵发性心房颤动合并稳定性冠心病气阴两虚证患者迷走神经功能,调节患者自主神经功能平衡,降低房颤负荷,且疗效可靠,无严重不良反应。
Objective To observe the effect of Tiaomai Mixture(Pulse-Regulating Mixture)on heart rate variability and AF burden in patients with paroxysmal AF(PAF)with qi-yin deficiency syndrome and stable coronary heart disease(SCAD).Methods In a randomized,controlled,parallel trial,56 patients with PAF,qi-yin deficiency syndrome,and SCAD were randomly divided into 30 in the control group and 26 in the treatment group.Both groups received basic routine treatment,while the treatment group was given additional Tiaomai Mixture.The treatment lasted four weeks.Heart rate variability index,AF burden,TCM syndrome score and adverse reactions were observed.Results Heart rate variability indexes,SDNN,RMSSD and HF were improved in both two groups(P<0.01),and the treatment group showed better improvement than the control group(P<0.01).LF/HF and AFB decreased significantly in both two groups(P<0.05),and there was significant difference between the two groups(P<0.05).In terms of TCM syndrome scores,the total effective rate was 90.0%in treatment group and 61.5%in the control group.The result in the treatment group were superior to those in the control group(P<0.05).Conclusion Tiaomai Mixture is effective in improving the vagus nerve function,regulating autonomic nerve function and reducing the atrial fibrillation load in patients with paroxysmal AF with qi-yin deficiency syndrome and stable coronary heart disease.No serious adverse reactions.
作者
李腾飞
张大炜
田伟
戴梅
韩垚
LI Tengfei;ZHANG Dawei;TIAN Wei;DAI Mei;HAN Yao(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010)
出处
《现代中医临床》
2023年第5期35-39,共5页
Modern Chinese Clinical Medicine
基金
北京中医药科技发展资金项目(No.QN2016-16)。
关键词
调脉合剂
心率变异性
房颤负荷
阵发性心房颤动
稳定性冠心病
气阴两虚证
Tiaomai mixture
atrial fibrillation burden
heart rate variability
paroxysmal atrial fibrillation
stable coronary heart disease
qi-yin deficiency
