摘要
目的比较丙泊酚、苯磺酸瑞马唑仑分别联合阿芬太尼在舒适化胃肠镜中的效果与安全。方法将拟行舒适化胃肠镜检查的患者50例,分为阿芬太尼+丙泊酚(P)组和阿芬太尼+瑞马唑仑(R)组,每组各25例。手术前两组均静脉注射阿芬太尼0.25 mg,注射30 s后,P组静脉注射丙泊酚2.5 mg/kg;R组静脉注射瑞马唑仑0.3 mg/kg。根据手术需要,P组追加丙泊酚30 mg/次;R组追加瑞马唑仑5 mg/次。监测两组患者的收缩压、舒张压、心率、SpO_(2)、呼吸频率值和MOAA/S评分以及手术时长、睁眼时间、满意度评分、术中不良反应。结果用药后及术毕时,R组的收缩压、舒张压、心率、呼吸频率值,MOAA/S评分均显著高于P组。R组的注射痛、低血压、窦缓、低氧饱和度发生率均低于P组。结论瑞马唑仑联合阿芬太尼用于舒适化胃镜的镇静效果与安全性均优于丙泊酚联合阿芬太尼。
Objective To compare the analgesic efficacy and safety of alfentanil combined with propofol or remimazolam in comfortable gastroscopy.Methods A total of 50 patients who were admitted to our hospital for comfortable gastroscopy were divided into two groups including the alfentanil+propofol(P)group and the alfentanil+remimazolam(R)group by random number table method.Before surgery,both groups were given an intravenous injection of alfentanil 0.25 mg,after 30 seconds,the P group was given an intravenous injection of propofol 2.5 mg/kg,and the R group was given an intravenous injection of remimazolam 0.3 mg/kg.According to the need during surgical procedures,the P group was given an additional 30 mg propofol each time,and the R group was given supplemented with 5 mg of remimazolam each time.The systolic blood pressure,diastolic blood pressure,heart rate,SpO_(2),respiratory rate,and MOAA/S score were dynamically monitored before and after medication and after surgery.Besides,the operation time,recovery time and the occurrence of adverse reactions patient satisfaction scores were recorded.Results The systolic blood pressure,diastolic blood pressure,heart rate,and respiratory rate,MOAA/S of the R group were significantly higher than those of the P group.The incidence of hypotension,hypoxia saturation,sinus bradycardia,and injection pain in the P group was higher than that in the R group.Conclusion The sedative effect and safety of remimazolam combined with alfentanil are better than those of propofol combined with alfentanil in comfortable gastroscope.
出处
《浙江临床医学》
2023年第10期1538-1540,共3页
Zhejiang Clinical Medical Journal
