摘要
目的探讨盐酸利托君治疗妊娠糖尿病孕妇先兆早产的疗效及安全性.方法选取2022年1月-2022年12月100例妊娠糖尿病先兆早产患者,以随机数字表法将其分成观察组与对照组,两组均采用常规治疗,在此基础上,对照组(n=50)加入硫酸镁,观察组(n=50)加入盐酸利托君.比较两组治疗效果及不良反应.结果观察组药物显效时间明显短于对照组,观察组妊娠期延长时间长于对照组,观察组新生儿体质量、1min阿氏评分高于对照组,差异显著(P<0.05);观察组治疗后IL-6、NO、PGE2水平低于对照组,差异显著(P<0.05);观察组治疗总有效率高于对照组,差异显著(P<0.05);治疗后,观察组FPG、2hPG、HbA1c高于对照组,但无显著差异(P>0.05);观察组不良反应发生率低于对照组,差异显著(P<0.05).结论盐酸利托君治疗妊娠糖尿病孕妇先兆早产具有明显效果,药效快,可延长妊娠期,改善新生儿结局,不良反应少,应用价值高.
Objective To investigate the efficacy and safety of ritodrine hydrochloride in the treatment of threatened preterm labor in pregnant women with diabetes.Methods From January 2022 to December 2022,100 cases of preterm labor with gestational diabetes were selected.They were divided into the observation group and the control group by the digital table method.Both groups were given conventional treatment.On this basis,the control group(n=50):magnesium sulfate was added,and the observation group(n=50):ritodrine hydrochloride was added.Compare the treatment effects and adverse reactions between the two groups.Results The effective time of the observation group was significantly shorter than that of the control group,and the pregnancy extension time of the observation group was longer than that of the control group.The body weight and 1-minute A-score of the observation group were higher than those of the control group,with significant differences(P<0.05);the levels of IL-6,NO,and PGE2 in the observation group were significantly lower than those in the control group after treatment(P<0.05);the total effective rate of the observation group was higher than that of the control group,with a significant difference(P<0.05);after treatment,the FPG,2hPG,and HbA1c in the observation group were higher than those in the control group,but there was no significant difference(P>0.05);the incidence of adverse reactions in the observation group was lower than that in the control group,with a significant difference(P<0.05).Conclusion Ritodrine hydrochloride has obvious effect in the treatment of threatened preterm labor in pregnant women with gestational diabetes.It has a rapid effect,can prolong the pregnancy period,improve the neonatal outcome,and has less adverse reactions and high application value.
作者
马燕
Ma Yan(Department of Obstetrics and Gynecology,Qinghai Red Cross Hospital,Xining,Qinghai 810000,China)
出处
《首都食品与医药》
2023年第21期46-48,共3页
Capital Food Medicine
关键词
盐酸利托君
妊娠糖尿病
先兆早产
新生儿
不良反应
Ritodrine hydrochloride
Pregnancy diabetes
Threatened preterm birth
Newborn
Adverse reactions
