摘要
目的研究通道弯数与长度对静脉曲张泡沫硬化疗法的泡沫稳定性影响。方法设置3组实验:实验组1通道弯数不同(A、B、C组弯数分别为1、2、3)、实验组2(对照组)通道总长度不同(A、B、C组总长度分别为2、6、10)、实验组3通道长短比例不同(A、B、C组长短边比值分别为1∶1、5∶1、9∶1)。选用5 mL注射器,液气比1∶4,并在室温环境下进行CO_(2)和空气的Tessari法制备泡沫实验。每组实验全程摄像,设置重复实验5次,通过视频回放方式获取析水时间、半衰期、析水率曲线等数据。结果实验组2中,CO_(2)泡沫除析水率40%和80%,A组与B组、C组都具有显著性差异。空气泡沫中,析水率20%和50%的B组与A组具有显著性差异;所有析水率下,C组与A组具有显著性差异。通道总长度对CO_(2)泡沫的影响更为显著。通道总长度越长,泡沫越稳定。实验组1与对照组对比,CO_(2)泡沫的实验组1析水率曲线明显高于对照组,而空气泡沫出现重合和交叉,差异不明显。实验组3和对照组对比,CO_(2)泡沫实验组3的曲线明显高于对照组,而空气泡沫只在析水达到100%时,实验组明显高于对照组。通道长短比例的影响在CO_(2)泡沫中较为明显。半衰期在CO_(2)泡沫中存在较大影响。结论制备泡沫的通道弯数增强了泡沫的稳定性,通道总长度增加对泡沫稳定性具有积极意义,而通道长短比例对泡沫稳定性的影响较大。研究结果对于临床制备泡沫以及其他泡沫的稳定性研究具有一定意义。
Objective To study the effect of channel bend number and length on foam stability of varicose vein foam sclerotherapy.Methods Three groups of experiments were set up:experimental group 1 with different channel turns(channel turn of subgroup A,B,C was 1,2,3,respectively),experimental group 2(control group)with different channel total lengths(total length of subgroup A,B,C was 2,6,10,respectively),experimental group 3 with different channel length ratios(ratio of long and short sides for subgroup A,B,C was 1∶1,5∶1,9∶1,respectively).A 5 mL syringe was used,the liquid-gas ratio was 1∶4,and the Tessari method of CO_(2) and air was used to prepare foam experiments at room temperature.The whole process of experiments on each group was photographed,and the experiment was repeated 5 times.Data such as water separation time,half-life,and water separation rate curve were obtained by video playback.Results In experimental group 2,the water removal rate of CO_(2) foam was 40% and 80%,and there were significant differences between subgroup A,subgroup B and subgroup C.In air foam,there is a significant difference between subgroup B and subgroup A with a water separation rate of 20% and 50%;for all water separation rates,subgroup C and subgroup A had a significant difference.The total length of the channel had a more significant impact on the CO_(2) foam.The longer the total length of the channel,the more stable the foam would be.Compared with control group,the CO_(2) foam in experimental group 1 had a significantly higher water separation rate curve than that in the control group,while the air foam overlapped and crossed,and the difference was not obvious.Compared with the control group,the curve of the CO_(2) foam in experimental group 3 was significantly higher than that in control group,while the air foam was only significantly higher than that in control group when the water separation reached 100%.The influence of the channel length ratio was more obvious in CO_(2) foam.The half-life had a greater impact in CO_(2)
作者
白逃萍
刘雨秋
蒋文涛
李亚兰
BAI Taoping;LIU Yuqiu;JIANG Wentao;LI Yalan(Provincial Key Laboratory of Biomechanical Engineering,Sichuan University,Chengdu 610065,China;School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China)
出处
《医用生物力学》
CAS
CSCD
北大核心
2023年第4期811-816,共6页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(12102281,11972239)
中国博士后科学基金项目(2021M702368)
四川省自然科学基金项目(2022NSFSC1967)
超声心脏电生理与生物力学四川省重点实验室开放课题(2022KFKT02)。
