摘要
目的探讨吉非替尼联合三维适形放疗治疗老年晚期表皮生长因子受体(EGFR)突变阳性非小细胞肺癌(NSCLC)近远期临床疗效及对血清肿瘤标志物指标的影响。方法选取2015年6月至2021年6月本院收治的60例老年晚期NSCLC患者作为研究对象,按照不同治疗方案分成观察组与对照组,每组30例。对照组仅采用单一三维适形放疗治疗,观察组在对照组治疗基础上给予吉非替尼治疗,比较两组近远期临床疗效、治疗前后血清肿瘤标志物指标及并发症发生情况。结果观察组临床疗效为80.00%,高于对照组的50.00%,差异有统计学意义(P<0.05)。观察组病情无进展生存时间、总生存时间均长于对照组差异有统计学意义(P<0.05)。治疗前,两组血清癌胚抗原(CEA)和细胞角蛋白21片段(CYFRA21-1)水平比较差异无统计学意义;治疗后,两组CEA和CYFRA21-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组恶心呕吐、皮疹、白细胞降低、肺炎发生率比较差异无统计学意义。结论吉非替尼联合三维适形放疗治疗老年晚期NSCLC疗效确切,能进一步改善患者的血清肿瘤标志物指标,且不会增加并发症的发生,值得临床推广应用。
Objective To investigate the short and long-term clinical efficacy of gefitinib combined with three-dimensional conformal radiotherapy in the treatment of advanced epidermal growth factor receptor(EGFR)mutation-positive non-small cell lung cancer(NSCLC)in the elderly and its influence on serum tumor markers.Methods A total of 60 elderly patients with advanced NSCLC admitted to our hospital from June 2015 to June 2021 were selected as the research subjects,and they were divided into the observation group and the control group according to different treatment regiments,with 30 cases in each group.The control group was treated with single three-dimensional conformal radiotherapy,and the observation group was treated with gefitinib on the basis of the control group,the short and long term clinical efficacy,serum tumor markers before and after treatment and complications were compared between the two groups.Results The clinical effect in the observation group was 80.00%,which was higher than 50.00%in control group,the difference was statistically significant(P<0.05).The progression-free survival time and overall survival time in the observation group were significantly longer than those in the control group(P<0.05).Before treatment,there were no significant differences in the serum levels of carcino embryonic antigen(CEA)and cytokeratin-21-fragment(CYFRA21-1)between the two groups;after treatment,the serum levels of CEA and CYFRA21-1 of the two groups were lower than those before treatment,and observation group was lower than control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of nausea,vomiting,rash,leukopenia and pneumonia between the two groups.Conclusion Gefitinib combined with three-dimensional conformal radiotherapy is effective in the treatment of elderly patients with advanced NSCLC,and can further improve the serum tumor markers of patients without increasing the incidence of complications,which is worthy of clinical promotion and applicati
作者
杨曼
李国文
邱文纯
YANG Man;LI Guowen;QIU Wenchun(The Third Department of Oncology,Chaozhou People's Hospital,Chaozhou,Guangdong,521000,China;The First Department of Oncology,Chaozhou People's Hospital,Chaozhou,Guangdong,521000,China)
出处
《当代医学》
2023年第12期36-39,共4页
Contemporary Medicine
关键词
吉非替尼
三维适形放疗
老年患者
晚期非小细胞肺癌
近远期疗效
血清肿瘤标志物
Gefitinib
Three-dimensional conformal radiotherapy
Elderly patients
Advanced non-small cell lung cancer
Short term and longterm efficacy
Serum tumor markers
