摘要
目的:研究阿替普酶急诊溶栓治疗在脑梗死患者治疗期间的应用效果,同时统计引发脑出血的风险因素。方法:选取2019年1月—2021年12月江苏省常州市肿瘤医院收治的脑梗死患者200例作为研究对象,采用双盲法分为研究组和对照组,各100例。对照组实施常规治疗,研究组实施阿替普酶急诊溶栓治疗。比较两组患者生活质量、治疗效果,分析阿替普酶急诊溶栓治疗引发脑出血的影响因素与多因素Logistics回归分析结果。结果:治疗后,研究组生理职能、社会交流、心理状态、总体健康评分高于对照组,差异有统计学意义(P<0.001);研究组总有效率高于对照组,差异有统计学意义(P=0.002);单因素分析结果显示,两组房颤史、大面积脑梗死、脑白质疏松及心力衰竭史占比比较,差异有统计学意义(P<0.05)。多因素Logistics回归分析结果显示,房颤史、大面积脑梗死、脑白质疏松及心力衰竭史是阿替普酶急诊溶栓治疗引发脑出血危险因素(P<0.05)。结论:阿普替酶急诊溶栓治疗可以有效提高患者生活质量,改善预后,但有房颤史、大面积脑梗死、脑白质疏松及心力衰竭史的患者发生脑出血风险较高,临床治疗中需给予重点关注。
Objective:To study the application effect of alteplase emergency thrombolytic therapy during the treatment of patients with cerebral infarction,and at the same time,to count the risk factors triggering cerebral hemorrhage.Methods:Two hundred patients with cerebral infarction admitted to Jiangsu Changzhou Cancer Hospital from January 2019 to December 2021 were selected as the study subjects,and were divided into a study group and a control group of one hundred cases each by double-blind method.The control group implemented conventional treatment,and the study group implemented alteplase emergency thrombolytic therapy.Compare the quality of life and treatment effect of patients in the two groups,and analyze the influencing factors of cerebral hemorrhage triggered by alteplase emergency thrombolytic treatment with the results of multifactorial Logistics regression analysis.Results:After treatment,the physiological function,social communication,psychological state,and general health scores of the study group were higher than those of the control group,and the difference was statistically significant(P<0.001);The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P=0.002);The results of univariate analysis showed that the percentage of history of atrial fibrillation,large cerebral infarction,cerebral leukoaraiosis and history of heart failure were compared between the two groups,and the difference was statistically significant(P<0.05);The results of multifactorial logistic regression analysis showed that history of atrial fibrillation,large cerebral infarction,cerebral leukoaraiosis and heart failure were risk factors for cerebral hemorrhage triggered by alteplase emergency thrombolytic therapy(P<0.05).Conclusion:Alteplase emergency thrombolytic therapy can effectively improve patients'quality of life and improve their prognosis,but patients with a history of atrial fibrillation,large cerebral infarction,cerebral leukoaraiosis and heart fa
作者
朱文博
Zhu Wenbo(Jiangsu Changzhou Cancer Hospital,Changzhou 213000,Jiangsu Province,China)
出处
《中外医药研究》
2023年第18期75-77,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
阿替普酶
溶栓
脑梗死
脑出血
Alteplase
Thrombolytic therapy
Cerebral infarction
Cerebral hemorrhage
