摘要
目的分析血浆纤维蛋白原和D-二聚体检测在急性缺血性脑卒中治疗中的应用价值。方法68例急性缺血性脑卒中患者为研究对象,回顾性分析患者的基线资料及预后情况,比较不同预后情况患者的血浆纤维蛋白原及D-二聚体水平。结果经临床有效治疗后,预后良好(预后良好组)患者占比为70.59%(48/68),植物生存(植物生存组)患者占比为20.59%(14/68),死亡(死亡组)患者占比为8.82%(6/68)。①不同预后情况患者的血浆纤维蛋白原水平组内比较:预后良好组患者治疗后3 d的血浆纤维蛋白原水平高于入院时,治疗后1、2周的血浆纤维蛋白原水平低于入院时,差异具有统计学意义(P<0.05)。植物生存组患者治疗后2周的血浆纤维蛋白原水平低于入院时,差异具有统计学意义(P<0.05)。组间比较:治疗后1、2周,死亡组患者的血浆纤维蛋白原水平(7.20±1.78)、(7.29±1.80)g/L高于植物生存组的(5.19±1.53)、(4.04±1.60)g/L及预后良好组的(4.03±0.87)、(2.11±0.71)g/L,植物生存组患者的血浆纤维蛋白原水平高于预后良好组,差异具有统计学意义(P<0.05)。②不同预后情况患者的D-二聚体水平组内比较:预后良好组患者治疗后3 d的D-二聚体水平高于入院时,治疗后1、2周的D-二聚体水平低于入院时,差异具有统计学意义(P<0.05)。组间比较:治疗后1、2周,死亡组患者的D-二聚体水平(1.92±0.54)、(2.04±0.41)mg/L高于植物生存组的(1.46±0.42)、(1.29±0.31)mg/L及预后良好组的(1.14±0.29)、(1.08±0.26)mg/L,植物生存组患者的D-二聚体水平高于预后良好组,差异具有统计学意义(P<0.05)。结论检测血浆纤维蛋白原和D-二聚体水平的变化能反映急性缺血性脑卒中患者的病情及预后情况,为临床治疗方案的制定及调整提供有益参考信息,值得重视采纳。
Objective To analyze the application value of plasma fibrinogen and D-dimer detection in the treatment of acute ischemic stroke.Methods 68 patients with acute ischemic stroke were studied.The baseline data and prognosis of 68 patients with acute ischemic stroke were retrospectively analyzed,and plasma fibrinogen and D-dimer levels of patients with different prognosis were compared.Results After clinical effective treatment,the proportion of patients with good prognosis(good prognosis group)was 70.59%(48/68),the proportion of patients with plant survival(plant survival group)was 20.59%(14/68),and the proportion of patients with death(death group)was 8.82%(6/68).(i)Intra-group comparison of plasma fibrinogen level of patients with different prognosis:the plasma fibrinogen level of good prognosis group at 3 d after treatment was higher than that at admission,and the plasma fibrinogen levels at 1 and 2 weeks after treatment was lower than those at admission.The differences were statistically significant(P<0.05).The plasma fibrinogen level in the plant survival group at 2 weeks after treatment was lower than that at admission,and the difference was statistically significant(P<0.05).Group comparison:at 1 and 2 weeks after treatment,the plasma fibrinogen levels were(7.20±1.78)and(7.29±1.80)g/L in the death group,which were higher than those in the plant survival group[(5.19±1.53)and(4.04±1.60)g/L]and those in the good prognosis group[(4.03±0.87)and(2.11±0.71)g/L];the plasma fibrinogen level in plant survival group was higher than that in good prognosis group;the differences were statistically significant(P<0.05).(ii)Intra-group comparison of D-dimer level of patients with different prognosis:the D-dimer level of good prognosis group at 3 d after treatment was higher than at admission,and the D-dimer levels at 1 and 2 weeks after treatment was lower than those at admission.The differences were statistically significant(P<0.05).Group comparison:at 1 and 2 weeks after treatment,the D-dimer levels were(1.92±0.54)and(
作者
杨晓光
YANG Xiao-guang(Department of Neurology,People's Hospital of Shenyang Economic and Technological Development Zone,Shenyang 110000,China)
出处
《中国现代药物应用》
2023年第20期66-69,共4页
Chinese Journal of Modern Drug Application
