摘要
反流性食管炎(reflux esophagitis,RE)在未经临床干预的情况下存在向巴雷特食管(Barrett’s esophagus,BE)发展的风险,而BE将进一步发展成为食管腺癌(esophageal adenocacinoma,EAC)。食管菌群的改变可介导食管炎症,影响RE的进展,促进“RE-BE”转变的进程。识别食管菌群的改变将进一步促进人类对RE和BE发病机制及进展的理解。本文主要综述了食管菌群对RE和BE影响,以及饮食、吸烟、药物、益生菌、抗生素或中药等对食管微生物群的调节作用,为临床RE和BE的诊断及个性化治疗提供新思路。
Reflux esophagitis(RE)is at risk of progressing to Barrett's esophagus(BE)without clinical intervention,which will further develop into esophageal adenocarcinoma(EAC).The esophageal microbiome is one of the hotspots in the research of esophageal diseases.It has been shown that the alteration of the esophageal microbiome can mediate esophageal inflammation and influence the progression of reflux esophagitis,promoting disease progression between RE-BE.Identifying the changes in esophageal flora will further promote our understanding of the pathogenesis and disease progression of RE and BE.This article mainly reviews the influence of esophageal flora on RE and BE,as well as the regulatory effect of diet,smoking,drugs,probiotics,synbiotics,antibiotics,or Traditional Chinese Medicine on esophageal flora,to provide new ideas for clinical diagnosis of RE and BE diseases and personalized treatment.
作者
郭政
唐艳萍(审校)
李明莉
杨磊
李培彩
刘磊
刘茜
弓艳霞
GUO Zheng;TANG Yanping;LI Mingli;YANG Lei;LI Peicai;LIU Lei;LIU Xi;GONG Yanxia(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Gastroenterology,Tianjin Nankai Hospital;Graduate School,Tianjin Medical University)
出处
《中国中西医结合消化杂志》
CAS
2023年第10期810-815,820,共7页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金(No:82274253、82204988、82074213)。
关键词
反流性食管炎
巴雷特食管
食管菌群
reflux esophagitis
Barrett's esophagus
esophageal microbiome
