摘要
The synthesis methods ofα-fluoro-arylketones were well-established through electrophilic/nucleophilic fluorination and transition metal catalyzed cross-coupling.However,due to the site selectivity and substrate restriction,only a few cases have been developed to affordα-alkyl-α-fluoro-alkylketones.Herein,we report a general and efficient method of preparing diverseα-alkyl-α-fluoro-alkylketones via nickelcatalyzed reductive coupling reaction of monofluoroalkyl triflates with low-cost industrial raw material alkyl carboxylic acids.These transformations demonstrate high efficiency,mild conditions,and excellent functional group compatibility.This strategy provides a general and efficient method for the synthesis ofα-alkyl-α-fluoro-alkylketones。
基金
the financial support of the National Key R&D Program of China(No.2021YFF0701700)
the National Science Foundation of China(Nos.22271264,21971228)。
