摘要
目的:探讨孟鲁司特钠联合布地奈德治疗小儿肺炎支原体感染致慢性咳嗽的效果。方法:选取2019年1月—2022年10月张家港市第三人民医院收治的肺炎支原体感染致慢性咳嗽患儿60例作为研究对象,采用随机数字表法分为两组,各30例。两组均给予阿奇霉素序贯疗法抗支原体感染,对照组在此基础上给予布地奈德治疗,观察组在对照组基础上应用孟鲁司特钠治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.005)。治疗后,观察组日间、夜间咳嗽症状评分低于对照组,差异有统计学意义(P<0.001)。观察组咳嗽消失时间短于对照组,差异有统计学意义(P<0.001)。治疗后,两组血清降钙素原、C反应蛋白、免疫球蛋白水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:孟鲁司特钠联合布地奈德治疗小儿肺炎支原体感染致慢性咳嗽的效果显著,可缓解咳嗽症状,减轻气道炎性反应,促进患儿康复。
Objective:To investigate the effect of montelukast sodium combined with budesonide in the treatment of chronic cough caused by mycoplasma pneumoniae infection in children.Methods:A total of 60 children with chronic cough caused by mycoplasma pneumoniae infection who were admitted to the Third People's Hospital of Zhangjiagang City from January 2019 to October 2022 were selected as the study subjects.The subjects were divided into two groups according to random number table method,with 30 cases in each group.Both groups received azithromycin sequential therapy for mycoplasma infection,the control group was treated with budesonide on the basis of above treatment and the observation group was treated with montelukast sodium on the basis of control group.Treatment effect was compared between two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.005).After treatment,the daytime and nighttime cough symptom scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.001).The cough disappearance time in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001).After treatment,the levels of serum procalcitonin,C-reactive protein and immunoglobulin in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Montelukast sodium combined with budesonide has a significant effect in the treatment of chronic cough caused by mycoplasma pneumoniae infection in children,which can alleviate cough symptoms,reduce airway inflammatory reaction and promote the recovery of children.
作者
马科星
Ma Kexing(Department of Pediatrics,The Third People's Hospital of Zhangjiagang City,Suzhou 215611,Jiangsu Province,China)
出处
《中国社区医师》
2023年第29期62-64,共3页
Chinese Community Doctors
关键词
肺炎
支原体感染
慢性咳嗽
布地奈德
孟鲁司特钠
Pneumonia
Mycoplasma infection
Chronic cough
Budesonide
Montelukast sodium
