摘要
目的:观察重复经颅磁刺激联合常规药物治疗老年精神分裂症患者的效果。方法:回顾性分析2021年4月至2022年4月该院收治的86例老年精神分裂症患者的临床资料,按照治疗方法不同将其分为观察组和对照组各43例。对照组予以常规药物治疗,观察组在对照组基础上联合重复经颅磁刺激治疗,两组均治疗2个月。比较两组临床疗效,治疗前后精神状态[阳性与阴性症状量表(PANSS)]评分、认知功能[蒙特利尔认知评估量表(MOCA)]评分、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]水平、神经递质(谷氨酸、多巴胺、γ-氨基丁酸)水平,以及不良反应发生率。结果:观察组治疗总有效率为90.70%(39/43),高于对照组的65.12%(28/43),差异有统计学意义(P<0.05);治疗后,观察组阳性量表、阴性量表、一般精神病理量表等PANSS评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组MOCA评分高于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-10、谷氨酸水平均高于对照组,IL-6、TNF-α、多巴胺、γ-氨基丁酸水平均低于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:重复经颅磁刺激联合常规药物治疗老年精神分裂症患者可提高治疗总有效率和认知功能评分,改善炎性因子和神经递质水平,降低精神状态评分,效果优于单纯常规药物治疗。
Objective:To observe effects of repetitive transcranial magnetic stimulation combined with conventional drugs in treatment of elderly patients with schizophrenia.Methods:The clinical data of 86 elderly patients with schizophrenia admitted to this hospital from April 2021 to April 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,43 cases in each group.The control group was treated with conventional drugs,while the observation group was treated with repetitive transcranial magnetic stimulation on the basis of that of the control group.Both groups were treated for 2 months.The clinical efficacy,the mental state[positive and negative syndrome scale(PANSS)]score,the cognitive function[Montreal cognitive assessment scale(MOCA)]score,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10)]levels,the neurotransmitters(glutamic acid,dopamine,γ-aminobutyric acid)levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 90.70%(39/43),which was higher than 65.12%(28/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the PANSS scores of the positive scale,negative scale and general psychopathology scale in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the MOCA score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-10 and glutamic acid in the observation group were higher than those in the control group,the levels of IL-6,TNF-α,dopamine andγ-aminobutyric acid were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there were no obvious adverse reactions in the two groups during the treatmen
作者
顾芸
杨晓龙
GU Yun;YANG Xiaolong(Geriatric Area of Department of Psychiatry of Taicang Third People’s Hospital,Suzhou 215400 Jiangsu,China)
出处
《中国民康医学》
2023年第20期102-105,共4页
Medical Journal of Chinese People’s Health
关键词
老年
精神分裂症
重复经颅磁刺激
认知功能
精神症状
炎性因子
神经递质
Elderly
Schizophrenia
Repetitive transcranial magnetic stimulation
Cognitive function
Mental symptom
Inflammatory factor
Neurotransmitter
