摘要
帕金森病(PD)是全球第二大神经系统退行性疾病,认知障碍是PD最常见的非运动症状之一,且患病率高、识别率低,因此早期诊断PD认知障碍至关重要。α-突触核蛋白(α-syn)是PD病理学标志——路易小体的主要成分,无论是散发性PD还是遗传因素导致的PD,异常聚集的α-syn均在其发病机制中发挥重要作用。PD认知障碍的发生发展与脑组织中α-syn病理沉积有关,而低水平的α-syn可能参与PD认知障碍的保护机制。因此,可通过检测人体血液、脑脊液、肠道黏膜等组织中的α-syn水平预测或筛选PD认知障碍。
Parkinson′s disease(PD)is the second most common neurodegenerative disease worldwide,and cognitive impairment is one of the most common non-motor symptoms of PD,with a high prevalence and low recognition rate,so early diagnosis of cognitive impairment in PD is crucial.α-synuclein(α-syn)is a major component of the pathological marker of PD,Lewy bodies,and abnormal aggregation ofα-syn plays an important role in the pathogenesis of PD,both in sporadic PD and in PD caused by genetic factors.The development of PD cognitive impairment is associated with pathological deposition ofα-syn in brain tissue,and low levels ofα-syn may be involved in the protective mechanism of PD cognitive impairment.Therefore,PD cognitive impairment can be predicted or screened by detectingα-syn levels in human blood,cerebrospinal fluid,intestinal mucosa and other tissues.
作者
杨川
白妍
李元
陈霞
王顺
YANG Chuan;BAI Yan;LI Yuan;CHEN Xia;WANG Shun(Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150036,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《医学综述》
CAS
2023年第17期3363-3369,共7页
Medical Recapitulate
