摘要
脑血管病(CVD)是慢性肾脏病(CKD)重要的并发症,也是CKD患者致残致死的重要原因。CKD并发CVD的危险因素主要分为传统危险因素(高龄、高血压、糖尿病、高脂血症等)和非传统危险因素(尿毒症毒素、钙磷代谢紊乱、肾性贫血、氧化应激、高同型半胱氨酸血症、蛋白尿、肾小球滤过率降低、营养不良、内皮功能不全、血管钙化等),上述各种危险因素导致CKD并发CVD的类型和影响机制也不同,而病因学分析有助于CKD患者并发CVD的一级预防与后续治疗。
Cerebrovascular disease(CVD)is an important complication of chronic kidney disease(CKD)and a major cause of disability and death in CKD patients.The risk factors of CKD complicated with cerebrovascular disease mainly include traditional risk factors(old age,hypertension,diabetes,hyperlipidemia,etc.)and non-traditional risk factors(uremic toxin,calcium and phosphorus metabolism disorder,renal anemia,oxidative stress,hyperhomocysteinemia,proteinuria,reduced glomerular filtration rate,malnutrition,endothelial dysfunction,vascular calcification,etc.).The above risk factors lead to different types and mechanisms of CKD complicated with CVD,and etiology analysis is helpful for the primary prevention and follow-up treatment of CKD patients complicated with CVD.
作者
朱艾琳
李银平
ZHU Ailin;LI Yinping(Department of Nephrology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Capital Medical University First Clinical School,Beijing 100053,China)
出处
《医学综述》
CAS
2023年第12期2401-2406,共6页
Medical Recapitulate
基金
首都医科大学本科生科研创新项目(XSKY2021320)。
关键词
慢性肾脏病
脑血管病
脑梗死
脑出血
Chronic kidney disease
Cerebrovascular disease
Stroke
Cerebral hemorrhage
