摘要
N^(6)-甲基腺苷(m^(6)A)广泛存在于真核生物RNA中,其可动态调节体内RNA代谢,维持RNA的稳定性,进而影响肿瘤细胞的发生、转移及血管的生成,在肿瘤的发生发展中发挥关键作用。其中,乳腺癌相关的m^(6)A修饰主要受甲基转移酶、去甲基转移酶及m^(6)A结合蛋白共同调控,可介导乳腺癌的发生发展。m^(6)A修饰可影响肿瘤微环境,未来深入研究m^(6)A修饰在乳腺癌肿瘤微环境及代谢中的作用,可以为乳腺癌的治疗提供新的靶点。
N^(6)-methyladenosine(m^(6)A)is widely present in eukaryotic RNA,which can dynamically regulate RNA metabolism and maintain RNA stability in vivo,thus affecting the occurrence,metastasis,and angiogenesis of tumor cells,and has a key role in the development of tumors.Among them,breast cancer-related m^(6)A modification is mainly regulated by methyltransferase,demethylases,and m^(6)A binding protein,which can mediate the occurrence and development of breast cancer.m^(6)A modification can affect the tumor microenvironment,and future in-depth studies of the role of m^(6)A modification in the tumor microenvironment and metabolism of breast cancer can provide new targets for the treatment of breast cancer.
作者
王琼鸽
刘俊秀
王锐
刘兰芳
梁云微
梁君伟
肖铄洋
胡潺潺
WANG Qiongge;LIU Junxiu;WANG Rui;LIU Lanfang;LIANG Yunwei;LIANG Junwei;XIAO Shuoyang;HU Chanchan(Department of Radiology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Department of Oncology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)
出处
《医学综述》
CAS
2023年第12期2350-2355,共6页
Medical Recapitulate
基金
河北省医学科学研究课题(20210440)。
