摘要
癫痫持续状态(SE)是神经科常见的急危重症,具有高发病率、高死亡率、高致残率等特点,其发病机制复杂,目前尚未完全明确。神经递质及其受体的功能异常会导致体内的兴奋-抑制失衡,在诱发和维持SE中发挥着核心作用,同时也是常规抗SE药物的作用靶点。遗传变异会诱导产生一系列与SE高度相关的疾病,多见于儿童。线粒体功能障碍则会导致大脑生理功能紊乱,进而诱发SE。此外,炎症、免疫紊乱以及血脑屏障通透性的增加也会促进SE的发生发展。未来,需要对SE的发病机制进行深入研究,以寻找新的致病途径,从而为SE的治疗提供新靶点。
Status epilepticus(SE)is a common acute and critical disease in neurology,having the characteristics of high morbidity,mortality and disability.The pathogenesis of SE is complex and has not yet been fully understood.Abnormal function of neurotransmitters and their receptors will lead to excitation-inhibition imbalance in the body,which plays a core role in inducing and maintaining SE,and is also the target of conventional anti-SE drugs.Genetic variation can induce a series of diseases highly related to SE,which are more common in children.Mitochondrial dysfunction will lead to brain physiological dysfunction,thus inducing SE.In addition,inflammation,immune disorder and the increase of blood-brain barrier permeability will also promote the occurrence and development of SE.In the future,the pathogenesis of SE needs to be further studied in order to find a new pathogenic pathway,so as to provide new targets for the treatment of SE.
作者
向开华
王天成
XIANG Kaihua;WANG Tiancheng(Epilepsy Center,Department of Neurology,Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《医学综述》
CAS
2023年第13期2601-2605,2610,共6页
Medical Recapitulate
基金
甘肃省科技计划项目(21YF1FA171)。
关键词
癫痫持续状态
神经递质
遗传变异
免疫
炎症
线粒体
血脑屏障
Status epilepticus
Neurotransmitter
Genetic variation
Immune
Inflammation
Mitochondrion
Blood-brain barrier
