摘要
膜性肾病(MN)属于原发性肾小球疾病,其病理改变是免疫复合物沉积于肾小球上皮细胞下导致补体激活,从而损伤肾小球滤过膜,使大量蛋白从尿液漏出,进而损伤肾脏。而磷脂酶A_(2)受体(PLA_(2)R)是MN主要靶抗原,其抗体可与足突细胞表面的PLA_(2)R抗原结合形成免疫复合物。抗PLA_(2)R抗体与MN诊断、病情程度、疗效、预后等密切相关,但抗PLA_(2)R抗体致病的免疫应答机制目前尚不明确。因此,阐明抗PLA_(2)R抗体与MN发生发展的具体关系,可以为MN的临床诊疗、预后评估等提供参考依据。
Membranous nephropathy(MN)is a primary glomerular disease.Its pathological changes are the deposition of immune complexes under glomerular epithelial cells,leading to complement activation,thereby damaging the glomerular filtration membrane,causing a large number of proteins to leak from the urine and damage the kidney.Phospholipase A_(2) receptor(PLA_(2)R)is the major target antigen of MN.Its antibody can combine with PLA_(2)R antigen on the surface of podocytes to form immune complex deposition.Anti-PLA_(2)R antibody is closely related to the diagnosis,disease severity,treatment effect and prognosis of MN.However,the immune response mechanism of anti-PLA_(2)R antibody in the pathogenesis of MN is still unclear.Therefore,clarifying the specific relationship between anti-PLA_(2)R antibody and the occurrence and development of MN may provide references for the clinical diagnosis,treatment and prognosis evaluation of MN.
作者
李雪
董大鹏
王海荣
LI Xue;DONG Dapeng;WANG Hairong(Department of Clinial Laboratory,Lequn Hospital of the First Hospital of Jilin University,Changchun 130031,China)
出处
《医学综述》
CAS
2023年第14期2835-2839,共5页
Medical Recapitulate
