期刊文献+

Pseudotyped lentiviral vectors:Ready for translation into targeted cancer gene therapy?

原文传递
导出
摘要 Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells,but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy.Over the past two decades,increasing studies have shown that lentiviral vectors(LVs)modified with different glycoproteins from a donating virus,a process referred to as pseudotyping,have altered tropism and display cell-type specificity in transduction,leading to selective tumor cell killing.This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy.This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies.The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed.
出处 《Genes & Diseases》 SCIE CSCD 2023年第5期1937-1955,共19页 基因与疾病(英文)
基金 supported by the National Natural Science Foundation of China(No.81872071) the Fundamental Research Funds for the Central Universities(China)(No.SWU120054) the Natural Science Foundation of Chongqing(China)(No.cstc2019jcyj-zdxmX0033) the Fundamental Research Funds for the Central Universities(China)(No.XYDS201912).
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部