摘要
代谢相关脂肪性肝病(metabolic-dysfunction-associated fatty liver disease,MAFLD)已成为我国慢性肝病的主要病因之一,其发病率呈逐年上升趋势。MAFLD是代谢综合征累及肝脏的表现,其发生发展与肠道菌群失调和代谢功能障碍等密切相关。由于发病机制尚不明确,目前依旧缺乏有效的药物治疗方法。肠道菌群与胆汁酸代谢密切相关,胆汁酸可靶向法尼醇X受体(farnesoid X receptor,FXR)信号通路负反馈调控肠道菌群,同时肠道菌群通过一系列复杂的生化反应影响胆汁酸代谢。大量研究发现MAFLD的免疫应答受损及全身低度慢性炎症可导致胆汁酸代谢紊乱。此外,MAFLD常伴随肠道菌群失调。本文就肠道菌群与胆汁酸代谢在MAFLD发生发展中的作用作一综述,以期探寻治疗MAFLD潜在的新的靶点。
Metabolic-dysfunction-associated fatty liver disease(MAFLD)has become one of the major causes of chronic liver disease in China and its incidence is increasing year by year.MAFLD is the hepatic manifestation of the metabolic syndrome.Gut microbiota dysbiosis and metabolic dysfunction are related to the occurrence and development of it.Regrettably,since the pathogenesis of MAFLD is not clearly defined,effective drug therapy is still unavailable.Changes in the composition of gut microbiota have been shown to be closely linked to alterations in bile acids.More exactly,bile acid metabolism can remodel gut microbiota composition through FXR signaling pathway.At the same time,gut microbiota participate in bile acid metabolism through a series of biochemical reactions.Numerous studies have found that impaired immune responsiveness and low-grade and chronic inflammation in MAFLD can cause the disorder of bile acid metabolism.In addition,the disease process is associated with dysregulation of gut microbiota.This review summarized current studies on the role of gut microbiota and bile acid metabolism in the occurrence and development of MAFLD in order to find new potential targets for the treatment of the disease.
作者
王昊阳
杨明华
梅璐
WANG Haoyang;YANG Minghua;MEI Lu(Department of Gastroenterology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,He′nan 450014,China)
出处
《中国微生态学杂志》
CAS
CSCD
2023年第8期989-992,F0003,共5页
Chinese Journal of Microecology
基金
国家重点研发计划项目(2020YFC2006100)
河南省重点研发与推广专项科技攻关项目(182102310179)
河南省医学科技攻关项目(2018020237,2018020228)。
关键词
代谢相关脂肪性肝病
肠道菌群
胆汁酸代谢
Metabolic-dysfunction-associated fatty liver disease
Gut microbiota
Bile acid metabolism
