摘要
目的探讨颅脑损伤者脑微结构异常多模态磁共振成像(MRI)结果同认知功能相关性。方法选取2021年7月-2022年12月收治的80例颅脑损伤患者,根据是否存在认知障碍,分成认知功能正常(对照组)40例与认知功能障碍(观察组)40例。两组均进行认知神经心理评估、进行MRI检查及多模态分析,对比两组评分结果及扩散张量参数,经Pearson相关性分析MRI数据与认知功能的相关性。结果观察组MMSE、ADL、HIS评分比对照组低,CDR、HAMD、HAMA评分比对照组高(P<0.05);观察组特定认知域功能评分分值低于对照组,扩散张量指标高于对照组(P<0.05),扩散张量参数同颅脑损伤者认知功能障碍呈现正相关(r=0.415,0.385,0.377,0.412,P<0.05)。结论颅脑损伤者,经多模态MRI检查可显示脑微结构异常,而微结构异常对认知障碍可造成影响。
Objective To explore correlation between multimodal magnetic resonance imaging(MRI)results of brain microstructure abnormalities and cognitive function of patients with traumatic brain injury.Methods The paper chose 80 patients with traumatic brain injury from July 2021 to December 2022,and divided them into control group of 40 cases with normal cognitive function and observation group of 40 cases with cognitive impairment based on cognitive impairment.Both groups were treated with cognitive neuropsychological assessment,MRI examination and multimodal analysis.Scoring results and diffusion tensor parameters between two groups were compared,correlation between MRI data and cognitive function was analyzed based on Pearson correlation analysis.Results MMSE,ADL and HIS scores of observation group were lower than control group,while the CDR,HAMD and HAMA scores were higher than control group(P<0.05).Specific cognitive domain functional scores of observation group were lower than control group,diffusion tensor index was higher than control group(P<0.05).Diffusion tensor parameter showed positive correlation with cognitive impairment of patients with brain injury(r=0.415,0.385,0.377,0.412,P<0.05).Conclusion Multimodal MRI examination can reveal abnormalities in brain microstructure of patients with traumatic brain injury,which can cause effect on cognitive impairment.
作者
陈安斯
程武
赖素勇
CHEN Ansi;CHENG Wu;LAI Suyong(Neurosurgery Department,Chaozhou City Central Hospital,Chaozhou,Guangdong 521000)
出处
《智慧健康》
2023年第19期5-8,13,共5页
Smart Healthcare
基金
潮州市卫生健康局科研项目《颅脑损伤患者脑微结构异常的多模态MRI研究及认知功能评估》(项目编号:潮卫科研2021109号)。
关键词
颅脑损伤
脑微结构异常
多模态
磁共振成像
认知功能
Craniocerebral injury
Abnormal brain microstructure
Multimodal
Magnetic resonance imaging
Cognitive function
