摘要
目的 研究0.1 g·L^(-1)低浓度阿托品滴眼液对近视儿童青少年脉络膜、视网膜厚度(RT)及血管系统的影响,分析低浓度阿托品影响近视的机制。方法 选取经散瞳检影验光等效球镜(SE)≤-0.50 D的近视儿童青少年123例,随机分为用药组(白天配戴框架眼镜,每晚0.1 g·L^(-1)低浓度阿托品滴眼1滴)70例以及对照组(仅白天配戴框架眼镜)61例。两组患儿基线时进行SE、眼轴长度(AL)、眼压(IOP)、黄斑中心凹下脉络膜厚度(SFCT)、浅层血管复合体(SVC)、深层血管复合体(DVC)及脉络膜毛细血管(CC)血流密度、RT等检查,并在3个月和6个月时进行两次随访和检查数据比较。结果 两组患儿基线年龄、性别比、IOP、SE、AL、SFCT、黄斑部微血管系统(SVC、DVC及CC)血流密度及平均RT比较,差异均无统计学意义(均为P>0.05)。两组患儿随访3个月和6个月时的SE、AL及SFCT比较,差异均有统计学意义(均为P<0.05)。与基线数据相比,对照组患儿随访6个月时的AL增长,用药组患儿随访3个月和6个月时的SFCT均增厚,差异均有统计学意义(均为P<0.05)。用药组患儿3个月、6个月随访时SVC、DVC及CC血流密度均高于对照组及基线数据,差异均有统计学意义(均为P<0.05)。用药组患儿与对照组比较,3个月、6个月随访时内环鼻侧RT较厚,6个月随访时外环上侧及外环鼻侧RT较厚,3个月、6个月随访时外环颞侧RT较厚,差异均有统计学意义(均为P<0.05)。结论 近视儿童青少年局部使用0.1 g·L^(-1)低浓度阿托品滴眼液可以改善视网膜脉络膜微循环,使脉络膜明显增厚,视网膜轻度增厚,从而延缓近视的进展。
Objective To explore the effect of 0.1 g·L^(-1) low-concentration atropine eyedrops on choroidal and retinal thickness(RT)and vascular system in children and adolescents with myopia and analyze the mechanism by which the low-concentration atropine affects myopia.Methods A total of 123 myopic children and adolescents with spherical equivalent(SE)less than or equal to-0.50 D were selected and randomly divided into the medication group(70 patients,wearing framed glasses during the day and dripping one drop of 0.1 g·L^(-1) low-concentration atropine eyedrops per night)and the control group(61 patients,only wearing framed glasses during the day).At baseline,SE,axial length(AL),intraocular pressure(IOP),subfoveal choroidal thickness(SFCT),superficial vascular complex(SVC),deep vascular complex(DVC)and choroidal capillary(CC)vessel density(VD),and RT were examined.Two follow-up checks were performed three and six months after treatment,and examination results were compared.Results There was no statistically significant difference in baseline age,gender ratio,IOP,SE,AL,SFCT,VD in the macular microvascular system(SVC,DVC and CC)and mean RT between the two groups(all P>0.05).Significant difference was found in SE,AL and SFCT between the two groups three and six months after treatment(all P<0.05).Compared with baseline data,the AL in the control group increased six months after treatment,and the SFCT in the medication group increased three and six months after treatment(all P<0.05).The VDs in SVC,DVC and CC in the medication group were higher than those in the control group and baseline data three and six months after treatment(all P<0.05).Compared with the control group,the RT on the nasal side of the inner ring and on the temporal side of the outer ring increased three and six months after treatment,and the RT on the superior and nasal sides of the outer ring increased six months after treatment in the medication group(all P<0.05).Conclusion Local use of 0.1 g·L^(-1) low-concentration atropine eyedrops in children and
作者
郑卓涛
张凌月
封炎
卢红薇
欧阳子婧
刘诗宇
徐丽雯
邓燕
殷小龙
ZHENG Zhuotao;ZHANG Lingyue;FENG Yan;LU Hongwei;OUYANG Zijing;LIU Shiyu;XU Liwen;DENG Yan;YIN Xiaolong(Ophthalmologic Center,the Second Affiliated Hospital of Nanchang University,Nanchang 330008,Jiangxi Province,China)
出处
《眼科新进展》
CAS
北大核心
2023年第11期887-892,共6页
Recent Advances in Ophthalmology
基金
江西省科学技术厅重点项目(编号:20202BBG72004)
学科交叉创新基金一般项目(编号:9166-27060003-YB18)
南昌大学二附院临床科研专项(编号:2019YNLZ12001)。
