摘要
目的:探讨SSTR亚型与胃肠胰神经内分泌肿瘤(GEP-NENs)病理特征及预后关系。方法:选取2016年1月-2021年1月期间我院收治的GEP-NENs 62例,经病理或活检确诊,探寻SSTR2、SSTR5与GEP-NENs病理特征的关系。患者均随访至2022年12月,随访时间24~60个月,记录患者肿瘤死亡情况。通过Cox比例风险回归分析GEP-NENs肿瘤死亡的影响因素。结果:SSTR2、SSTR5在不同性别、年龄、肿瘤部位、是否脉管神经侵犯、是否远处转移患者中的阳性率比较,差异无统计学意义(P>0.05),SSTR2阳性率在肿瘤直径>2cm、低分化、淋巴结转移、TNM分期中Ⅲ+Ⅳ期患者中的占比低于肿瘤直径≤2cm、高及中分化、淋巴结未转移、TNM分期中Ⅰ+Ⅱ期患者(P<0.05),SSTR5阳性率在肿瘤直径>2cm、低分化、淋巴结转移、TNM分期中Ⅲ+Ⅳ期患者中的占比低于肿瘤直径≤2cm、高及中分化、淋巴结未转移、TNM分期中Ⅰ+Ⅱ期患者(P<0.05)。多因素Cox比例风险回归分析显示,肿瘤直径>2cm、低分化及SSTR2、SSTR5的阳性低表达是影响GEP-NENs患者肿瘤死亡的独立风险因素(P<0.05)。结论:SSTR2、SSTR5的阳性表达与GEP-NENs的肿瘤直径、分化程度、淋巴结转移及TNM分期关系密切,且两个指标阳性率低是GEP-NENs患者肿瘤死亡的风险因素。
Objective:To investigate the relationship between SSTR subtype and gastrointestinal and pancreatic neuroendocrine tumors(GEP-NENs).Methods:62 cases of GEP-NENs admitted to our hospital from January 2016 to January 2021 were selected.They were confirmed by pathology or biopsy.The relationship between SSTR2,SSTR5 and GEP-NENs pathological features was explored.All patients were followed up for 24 to 60 months until December 2022,and tumor death was recorded.The factors of GEP-NENs tumor death were analyzed by Cox proportional risk regression.Results:There was no significant difference in the positive rates of SSTR2 and SSTR5 in patients with different genders,ages,tumor sites,vascular nerve invasion or distant metastasis(P>0.05).The positive rate of SSTR2 in patients with tumor diameter>2cm,low differentiation,lymph node metastasis and TNM stageⅢ+Ⅳwas lower than that in patients with tumor diameter≤2cm,high/medium differentiation,lymph node metastasis and TNM stageⅠ+Ⅱ(P<0.05).The positive rate of SSTR5 in patients with tumor diameter>2cm,low differentiation,lymph node metastasis and TNM stageⅢ+Ⅳwas lower than that in patients with tumor diameter≤2cm,high and moderate differentiation,no lymph node metastasis and TNM stageⅠ+Ⅱ(P<0.05).Multivariate Cox proportional hazard regression analysis showed that tumor diameter>2cm,low differentiation and low positive expression of SSTR2 and SSTR5 were independent risk factors for tumor death in GEP-NENs patients(P<0.05).Conclusion:The positive expression of SSTR2 and SSTR5 was closely related to the tumor diameter,differentiation degree,lymph node metastasis and TNM stage of GEP-NENs patients,and the low positive rate of the two indicators was a risk factor for tumor death in GEP-NENs patients.
作者
陈贤翔
CHEN Xianxiang(Zhangzhou Zhengxing Hospital,Zhangzhou City,Fujian Province 363000)
出处
《医学理论与实践》
2023年第21期3613-3615,3619,共4页
The Journal of Medical Theory and Practice
关键词
胃肠胰神经内分泌肿瘤
SSTR亚型
病理特征
预后
Gastrointestinal and pancreatic neuroendocrine tumors
SSTR subtype
Pathological features
Prognosis
