摘要
目的探讨围手术期口服芪苈强心胶囊联合水化预防老年冠心病患者经皮冠状动脉介入(PCI)术后造影剂肾病(CIN)的效果。方法连续选取2020年9月至2021年12月于赣州市人民医院心内科拟行PCI术的200例老年冠心病患者作为研究对象,采用随机数字表法分为试验组与对照组,每组各100例。对照组给予规范冠心病二级预防+水化治疗,试验组在对照组的基础上于PCI术前3 d和术后3 d口服芪苈强心胶囊,比较两组患者的血肌酐(SCr)、血尿素氮(BUN)、胱抑素C(Cys-C)、C反应蛋白(CRP)、白细胞介素6(IL-6)、血清β_(2)微球蛋白(β_(2)-MG)、肿瘤坏死因子-α(TNF-α)水平变化。结果试验组术后3 d的SCr、BUN、Cys-C、血清β_(2)-MG水平低于对照组,内生肌酐清除率(CCr)高于对照组,差异有统计学意义(P<0.05);两组患者术后3 d的CRP、IL-6水平均升高,且试验组术后3 d的CRP、IL-6水平高于对照组,差异有统计学意义(P<0.05),两组患者术后3 d的TNF-α水平均降低,且试验组术后3 d的TNF-α水平低于对照组,差异有统计学意义(P<0.05)。试验组的术后CIN发生率低于对照组,差异有统计学意义(P<0.05)。结论芪苈强心胶囊可减轻造影剂肾功能损害,降低老年冠心病患者PCI术后CIN发生率。
Objective To investigate the application effect of perioperative oral administration of Qiliqiangxin Capsules combined with hydration in the prevention of contrast-induced nephropathy(CIN)in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 200 elderly patients with coronary heart disease who were scheduled to undergo PCI surgery in the Department of Cardiology of Ganzhou People's Hospital from September 2020 to December 2021 were continuously selected as the research objects.All the patients were randomly divided into the experimental group(100 cases)and the control group(100 cases)according to random number table method.The control group was treated with standard secondary prevention of coronary heart disease and hydration therapy.The experimental group was treated with Qiliqiangxin Capsules orally preoperative and postoperative 3 days on the basis of the treatment in the control group.The levels of serum creatinine(SCr),blood urea nitrogen(BUN),cystatin C(Cys-C),C-reactive protein(CRP),interleukin 6(IL-6),serumβ_(2) microglobulin(β_(2)-MG)and tumor necrosis factor-α(TNF-α)were compared between the two groups.Results The levels of SCr,BUN,Cys-C and serumβ_(2)-MG in the experimental group at 3 days after surgery were lower than those in the control group,and the level of endogenous creatinine clearance(CCr)in the experimental group at 3 days after surgery was higher than that in the control group,the differences were statistically significant(P<0.05).The levels of CRP and IL-6 were in-creased in the two groups at 3 days after surgery,and the levels of CRP and IL-6 in the experimental group at 3 days after surgery were higher than those in the control group,with statistical significance(P<0.05).The levels of TNF-αwere de-creased in the two groups at 3 days after surgery,and the level of TNF-αin the experimental group at 3 days after surgery were lower than those in the control group,the difference were statistically significant(P<0.05).The inciden
作者
严娜
杨江永
罗建平
YAN Na;YANG Jiangyong;LUO Jianping(Department of Cardiology,Ganzhou People's Hospital,Jiangxi Province,Ganzhou 341000,China;Department of Cardiology,Ganzhou Municipal Hospital,Jiangxi Province,Ganzhou 341000,China)
出处
《中国当代医药》
CAS
2023年第30期74-78,共5页
China Modern Medicine
基金
江西省中医药管理局科技计划课题(2020A0055)。
关键词
冠心病
芪苈强心胶囊
水化疗法
造影剂肾病
经皮冠状动脉介入术
Coronary heart disease
Qiliqiangxin Capsules
Hydration therapy
Contrast-induced nephropathy
Percuta-neous coronary intervention
