摘要
线粒体网络重塑是维持细胞稳态的重要过程,与线粒体的功能密切相关。新线粒体的形成(生物发生)和受损线粒体的清除(线粒体自噬)之间的相互作用是线粒体网络重塑的重要表现方式。此外,线粒体的裂变和融合是生物发生和线粒体自噬之间的桥梁。近年来,这些过程的重要性已经在多种组织和细胞类型以及各种条件下被描述出来。比如在巨噬细胞的极化及效应器功能过程中,可以观察到线粒体网络的强健重塑。研究也揭示线粒体形态结构和代谢改变在调控巨噬细胞功能中的重要作用,所以相应的如何调控线粒体网络的重塑同样在巨噬细胞免疫反应中起着至关重要的作用。该文主要总结了线粒体网络重塑中,线粒体新生、裂变、融合和自噬的分子机制,并整合这些机制,探讨它们在巨噬细胞极化、炎症小体激活和胞噬作用中的生物作用。
Remodeling of the mitochondrial network is an important process in the maintenance of cellular homeostasis and is closely related to mitochondrial function.Interactions between the biogenesis of new mitochondria and the clearance of damaged mitochondria(mitophagy)is an important manifestation of mitochondrial network remodeling.Mitochondrial fission and fusion act as a bridge between biogenesis and mitophagy.In recent years,the importance of these processes has been described in a variety of tissues and cell types and under a variety of conditions.For example,robust remodeling of the mitochondrial network has been reported during the polarization and effector function of macrophages.Previous studies have also revealed the important role of mitochondrial morphological structure and metabolic changes in regulating the function of macrophages.Therefore,the processes that regulate remodeling of the mitochondrial network also play a crucial role in the immune response of macrophages.In this paper,we focus on the molecular mechanisms of mitochondrial regeneration,fission,fusion,and mitophagy in the process of mitochondrial network remodeling,and integrate these mechanisms to investigate their biological roles in macrophage polarization,inflammasome activation,and efferocytosis.
作者
朱莲莲
孔祥敏
朱伟
ZHU Lianlian;KONG Xiangmin;ZHU Wei(Department of Cardiology of The Second Affliated Hospital,School of Medicine,Zhejiang University;Cardiovascular Key Laboratory of Zhejiang Province,Hangzhou 310009,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2023年第7期656-662,共7页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81970230)。
