摘要
猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)现在已经影响到全世界的养猪产业,危害整个产业链的经济效益。一些miRNA在抵御病毒方面具有不错的效果,已成为目前病毒和分子领域的热点之一。猪乳外泌体中也存在miRNA,且具有防御猪繁殖与呼吸综合征病毒(PRRSV)的作用,但目前该方向的研究尚无较大成果的突破,具有广阔的研究前景。文章论述了PRRSV的致病机制及防治研究进展,总结了外泌体中miRNA的作用机制及对PRRSV的作用,为后续猪乳外泌体分离检测以及筛选出相关miRNA、推进后续PRRS疫苗研发提供参考。
PRRS is now affecting the pig industry worldwide,jeopardizing the economics of the entire chain.Some mirnas have a good effect on virus resistance,which has become one of the hot spots in the field of viruses and molecules.miRNA also exists in porcine milk exosomes,which can protect against PRRSV.However,there has been no major breakthrough in this direction,and it has broad research prospects.The paper reviewed the pathogenesis and prevention of PRRSV,summarized the action mechanism of mirnas in exosomes and their effects on PRRSV,and provided references for the subsequent isolation and detection of porcine milk exosomes,screening of related mirnas,and promoting the subsequent research and development of PRRS vaccine.
作者
奚德鑫
付诗涵
蔡锦顺
Xi Dexin;Fu Shihan;Cai Jinshun(College of Agriculture,Yanbian University,Jilin Yanji 133000)
出处
《现代畜牧兽医》
2023年第10期92-96,共5页
Modern Journal of Animal Husbandry and Veterinary Medicine
基金
吉林省科技厅项目(20210101371JC)。
