摘要
目的比较初治菌阳2型糖尿病合并肺结核患者接受固定剂量联合(fixed-dose combination,FDC)与单独片剂方案(separate tablet regimens,ST)的治疗的效果和不良反应。方法回顾性分析广州市胸科医院2019年1月至2022年6月108例收治的2型糖尿病合并肺结核的初治菌阳患者,其中56例接受FDC治疗的患者为FDC组,52例接受ST方案治疗的患者为ST组。比较两组患者的治疗效果(治疗2、5、6月的菌阳转阴率,治疗后肺部病灶吸收情况)和不良事件(肝损伤、胃肠反应、高尿酸血症、神经系统症状、视觉异常)的发生率。结果(1)FDC组治疗2、5、6个月菌阳转阴率均较ST组升高,尤其是治疗2月的菌阳转阴率存在统计差异(P<0.05);(2)治疗后FDC组的病灶总吸收率较ST组更高(P<0.05);(3)治疗期间2组均出现一系列不良反应,如肝损伤、胃肠道反应等,虽然FDC组不良反应的发生率稍低于ST组,但差异无显著性(P>0.05)。结论FDC可帮助糖尿病患者提升2月末的痰菌阴转率,同时增加其病灶吸收范围,且在整个治疗过程中,用药不良反应发生率未增加,值得积极推广应用。
Objective To compare the effects and adverse effects of fixed dose combination(fix-dose combination FDC)with tablet alone for type 2 diabetes(separate tablet regimens ST).Methods 108 patients with type 2 diabetes with tuberculosis from January 2019 to June 2022,among which 56 patients treated with FDC were FDC group and 52 patients treated with ST regimen were ST group.The effect of treatment(positive turning rate of treatment 2,5,June,absorption of pulmonary lesions after treatment)and the incidence of adverse events(liver injury,gastrointestinal reactions,hyperuricemia,neurological symptoms,visual abnormalities)were compared in the two groups.Results(1)The rates of bacteria in 2,5 and 6 months were higher compared with ST group,especially the rate in 2 months(P<0.05);(2)the total absorption rate of FDC group was higher than that in ST group(P<0.05);(3)a series of adverse reactions during treatment,such as liver injury,gastrointestinal reaction,etc.Although the incidence of adverse reactions in FDC group was slightly lower than that in ST group,the difference was not significant(P>0.05).Conclusion FDC can help diabetic patients improve the conversion rate of sputum bacteria at the end of February,and increase the absorption range of their lesions.Moreover,the incidence of adverse drug reactions in the whole treatment process did not increase,which is worthy of active promotion and application.
作者
顾玉虹
张雅惠
何刚
伍小英
Gu Yu-hong;Zhang Ya-hui;He Gang;Wu Xiao-ying(Guangzhou Chest Hospital,Guangzhou 510000,Guangdong Province,China;State Key Laboratory of Respiratory Diseases,Guangzhou 510000,Guangdong Province,China)
出处
《罕少疾病杂志》
2023年第10期48-49,共2页
Journal of Rare and Uncommon Diseases
关键词
肺结核
糖尿病
固定剂量
分开的片剂
治疗效果
不良反应
Tuberculosis
Diabetes Mellitus
Fixed Dose
Separate Tablets
Treatment Effect
Adverse Reactions
