摘要
目的:研究哌拉西林他唑巴坦配合左氧氟沙星对支气管扩张患者的治疗效果。方法:择取赣州市赣县区人民医院2021年6月至2023年4月就诊的80例支气管扩张患者,通过随机数字表法分对照组和观察组,每组40例。对照组患者应用左氧氟沙星治疗,观察组患者在对照组基础上联合哌拉西林他唑巴坦治疗,比较两组患者的治疗效果。结果:观察组患者临床症状持续时间均短于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者第1秒用力呼气量(FEV1)、用力肺活量(FVC)、呼气流量峰值(PEF)、最大通气量(MVV)、FEV1/FVC均高于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者白细胞(WBC)、中性粒细胞计数(NEUT)、C反应蛋白(CRP)、白细胞介素–6(IL–6)、红细胞沉降率(ESR)、降钙素原(PCT)均低于对照组,差异具有统计学意义(P<0.05)。结论:哌拉西林他唑巴坦配合左氧氟沙星治疗支气管扩张患者,能有效缩短临床症状持续时间,改善肺功能以及降低炎症因子水平。
Objective To study the therapeutic effect of piperacillin tazobactam combined with levofloxacin in patients with bronchiectasis.Methods A total of 80 patients with bronchiectasis from Ganxian District People's Hospital of Ganzhou City from June 2021 to April 2023 were selected and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with levofloxacin,and the observation group was treated with piperacillin tazobactam on the basis of the control group,and the therapeutic effects of the two groups were compared.Results The duration of clinical symptoms in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).After treatment,forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF),maximal voluntary ventilation(MVV)and FEV1/FVC in the observation group were higher than those in the control group,with statistical significance(P<0.05).After treatment,white blood cells(WBC),neutrophil(NEUT),C-reactive protein(CRP),interleukin-6(IL-6),erythrocyte sedimentation rate(ESR)and procalcitonin(PCT)in the observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Piperacillin tazobactam combined with levofloxacin can effectively shorten the duration of clinical symptoms,improve lung function and reduce the level of inflammatory factors in patients with bronchiectasis.
作者
徐清锋
王小梅
廖杨芬
罗水香
朱美勤
XU Qingfeng;WANG Xiaomei;LIAO Yangfen;LUO Shuixiang;ZHU Meiqin(Ganxian District People's Hospital of Ganzhou City,Jiangxi Ganzhou 341100;Ganxian district Nantang health center of Ganzhou City,Jiangxi Ganzhou 341100)
出处
《深圳中西医结合杂志》
2023年第16期113-115,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
赣州市指导性科技计划项目(GZ2021ZSF393)。
