摘要
目的 报告1例氟康唑致肝损伤的病例,并分析氟康唑致药物性肝损伤的危险因素。方法 通过查阅文献及不良反应关联性评价、Roussel Uclaf因果关系评价(the roussel uclaf assessment method,RUCAM),分析药物性肝损伤后处理及治疗,并探讨氟康唑致肝损伤的危险因素。结果 经不良反应关联性评价及RUCAM因果关系评价,该病例氟康唑致肝损伤关联性等级分别为“肯定”及“极可能”。氟康唑致肝损伤机制不明,慢性肝病、肾功能不全、人类免疫缺陷病毒(HIV)、高龄等可能为氟康唑致肝损伤的危险因素。结论 临床在使用氟康唑时应注意监测患者肝功能,以避免肝损伤/肝衰竭的发生。
Objective To report a case of fluconazole-induced liver injury,and to analyze the risk factors for drug-induced liver injury caused by fluconazole.Methods By reviewing the literature and evaluating the causal relationship between adverse reaction association/RUCAM,the post-treatment and treatment of drug-induced liver injury were analyzed,and the risk factors for fluconazole-induced liver injury were discussed.Results After the evaluation of the association of adverse reactions and the evaluation of the causal relationship of RUCAM,the correlation level of fluconazole liver injury in this case was"positive"and"very likely",respectively.The mechanism of fluconazole-induced liver injury is unknown,and chronic liver disease,renal insufficiency,HIV,and advanced age may be risk factors for fluconazole-induced liver injury.Conclusion Clinical use of fluconazole should pay attention to monitoring liver function,to avoid the occurrence of liver injury/liver failure.
作者
孙飞
包丽
龚汉明
Sun Fei;Bao Li;Gong Hanming(The Yunnan New Kunhua Hospital,Kunming,Yunnan 650301;The First People's Hospital of Yunnan,Kunming,Yunnan 650032)
出处
《基层医学论坛》
2023年第28期133-135,共3页
The Medical Forum
基金
“螳川人才培育”人才工作项目(安人才办[2020]6号)。
关键词
氟康唑
肝衰竭
肝功能
不良反应
Fluconazole
Liver failure
Liver function
Adverse reactions
