摘要
目的探究载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、C-反应蛋白(CRP)及尿糖检测在2型糖尿病病情进展中的临床意义。方法随机选取2020年5月—2022年5月在崇义县人民医院诊断及治疗的99例2型糖尿病患者作为研究对象,根据患者是否发生并发症分为2型糖尿病组(42例)及糖尿病并发症组(57例)2组,选取同时期在该院进行健康体检的50名健康受检者作为对照组。收集所有研究对象血清及尿液,检测不同病情进展患者血清ApoA1、ApoB、CRP水平及尿糖水平。建立受试者特征工作(ROC)曲线,分析ApoA1、ApoB、CRP及尿糖单独或联合检测对2型糖尿病病情进展的诊断价值。结果与对照组对比,2型糖尿病组患者血清ApoA1明显降低,血清ApoB、CRP及尿糖水平均明显升高(P<0.05);与2型糖尿病组对比,糖尿病并发症组患者血清ApoA1明显降低,血清ApoB、CRP及尿糖水平均明显升高(P<0.05);建立ROC曲线发现,ApoA1、ApoB、CRP及尿糖单独或联合检测的曲线下面积分别为0.738、0.752、0.696、0.709、0.907,单独或联合检测对2型糖尿病患者病情进展均具有一定价值,且联合检测具有更高的价值(P<0.05)。结论ApoA1、ApoB、CRP及尿糖水平与2型糖尿病病情进展具有重要关系,且联合检测对2型糖尿病病情进展的诊断价值较高。
Objective To investigate the clinical significance of apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),C-reactive protein(CRP)and urine glucose testing in the progression of type 2 diabetes mellitus.Methods A total of 99 patients with type 2 diabetes diagnosed and treated in The Chongyi County Reople's hospital from May 2020 to February 2022 were randomly selected as the research objects,and 99 patients with type 2 diabetes were divided into type 2 diabetes group(n=42 cases)and diabetes complication group(n=57 cases)according to whether complications occurred.50 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.Serum and urine were collected from all study subjects,and serum ApoA1,ApoB,CRP levels and urine glucose levels were measured in patients with different disease progression.ROC curves were established to analyze the diagnostic value of ApoA1,ApoB,CRP and urine glucose alone or in combination on the progression of type 2 diabetes mellitus.Results Compared with the control group,the serum ApoA1 in type 2 diabetes group was significantly lower,and the serum ApoB,CRP and urine sugar water were significantly higher(P<0.05).Compared with the type 2 diabetes group,the serum ApoA1 in the diabetes complication group was significantly lower,and the serum ApoB,CRP and urine sugar water were significantly higher(P<0.05).The ROC curve was established.The results showed that the areas under the curve of ApoA1,ApoB,CRP and urine sugar detected individually or jointly were 0.738,0.752,0.696,0.709 and 0.907,respectively.The single or combined detection had a certain value for the disease progression of type 2 diabetes patients,and the combined detection had a higher value(P<0.05).Conclusion ApoA1,ApoB,CRP and urine glucose levels have an important relationship with the progression of type 2 diabetes,and their combined test has the highest diagnostic value for the progression of type 2 diabetes.
作者
甘丽君
Gan Lijun(The Chongyi County People's Hospital,Ganzhou,Jiangxi 341300)
出处
《基层医学论坛》
2023年第28期80-82,150,共4页
The Medical Forum
关键词
2型糖尿病
载脂蛋白A1B
CRP
尿糖
Type 2 diabetesmellitus
Apolipoprotein A1B
CRP
Urine glucose
