摘要
肠道微生物群在宿主代谢和炎性反应调节中发挥重要作用,许多疾病的发生与肠道菌群失衡密切相关。Akkermansia muciniphila(A.muciniphila)是疣微菌门中第一个被成功分离鉴定和培养的肠道共生菌,最初从人类粪便样本中被分离出来,因具备黏蛋白的降解特性,使其成为肠道黏膜中的关键菌种之一。不断有研究表明A.muciniphila的丰度与动物和人体的健康密切相关,使其成为近年来肠道微生态和益生菌的研究热点。此外,A.muciniphila的丰度在炎症性肠病(主要是溃疡性结肠炎)和代谢紊乱患者中降低,这表明它可能具有潜在的抗炎特性。本文将系统阐述A.muciniphila与肠道免疫和系统代谢疾病之间的关联,重点探讨其在改善肠道屏障、免疫应答及宿主代谢方面的功能和可能作用机制,为以A.muciniphila为基础开发疾病治疗新方法提供证据和思路。
Gut microbiota plays an important role in the regulation of host metabolism and low-grade inflammation,and the occurrence of many diseases is closely related to gut microbiota dysbiosis.Akkermansia muciniphila(A.muciniphila)is the only cultivated intestinal representative of the Verrucomicrobia and was isolated from a human fecal sample.Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells.There has also been a growing interest in A.muciniphila,due to its association with health in animals and humans.Notably,reduced levels of A.muciniphila have been observed in patients with inflammatory bowel diseases(mainly ulcerative colitis)and metabolic disorders,which suggests it may have potential anti-inflammatory properties.The aims of this review are to systemically summarize the existing data on the relationship between the A.muciniphila with intestinal immunity and the metabolic diseases.With a specific focus on the mechanisms of inflammatory bowel diseases and metabolic disorders in both animals and humans,which is expected to provide evidence and routes for effective utilization of this bacterial species.
作者
陈菁青
郑建华
董巧燕
武文卿
孙天奇
邱业峰
张睿
CHEN Jingqing;ZHENG Jianhua;DONG Qiaoyan;WU Wenqing;SUN Tianqi;QIU Yefeng;ZHANG Rui(Laboratory Animal Center of the Academy of Military Medical Sciences,Beijing 100071,China)
出处
《实验动物科学》
2023年第5期80-85,共6页
Laboratory Animal Science
基金
全军实验动物专项课题(SYDW[2021]06)
军事医学研究院青年人才基金(AMMS-QNPY-2022-019)。
