摘要
儿童造血细胞移植(HSCT)术后可能会导致内皮细胞持续活化,诱导促凝、促炎及促凋亡,从而导致内皮细胞功能障碍及损伤,出现危及生命的并发症。有效管理内皮细胞活化、损伤和功能障碍对于改善HSCT后患者的预后很重要。现就HSCT术后静脉闭塞/窦阻塞综合征及移植相关血栓性微血管病的流行病学特征、发病机制及治疗的最新进展进行综述。
Hematopoietic stem cell transplantation(HSCT)in children may lead to endothelial cell activation,and the induction of procoagulant,proinflammatory,and proapoptotic mediators,resulting in endothelial cell dysfunction and injury,as well as life-threatening complications.An effective management of endothelial cell activation,injury,and dysfunction is important for improving outcomes after HSCT.This article reviews the recent advances in the epidemiological features,pathogenesis and treatment of veno-occlusive disease/sinusoidal obstruction syndrome and transplant-related thrombotic microangiopathy after HSCT.
作者
魏昂
王天有
秦茂权
Wei Ang;Wang Tianyou;Qin Maoquan(National Center for Children′s Health Hematology Center,Beijing Children′s Hospital,Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Key Laboratory of Major Disease in Children Ministry of Education,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2023年第10期785-789,共5页
Chinese Journal of Applied Clinical Pediatrics
基金
国家科技重大专项(2017ZX09304029001)。
关键词
造血干细胞移植
内皮损伤
发病机制
儿童
Hematopoietic stem cell transplantation
Endothelial injury
Mechanism
Child
