摘要
目的探讨血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平与慢性阻塞性肺疾病急性加重期(AECOPD)患者临床预后的相关性,为预测患者预后提供依据。方法本研究采用前瞻性研究方法。抽取2019年4月至2020年4月驻马店市中心医院收治的85例AECOPD患者为研究对象。治疗前检测患者血清IL-6、IL-8水平,后对患者开展系统化的综合治疗,同时开展24个月随访,以患者病死或随访截止时间为观察终点,统计患者生存情况。设计患者基线资料调查表,统计并记录研究所需资料,将可能的因素纳入,采用Cox回归分析重点分析血清IL-6、IL-8水平与AECOPD患者临床预后的相关性。结果观察期间,85例AECOPD患者病死21例,占比24.71%(21/85)。预后不良患者治疗前血清IL-6、IL-8水平均高于预后良好患者(P均<0.05)。预后不良患者与预后良好患者基线资料比较,差异均未见统计学意义(P均>0.05)。Cox回归分析结果显示,血清IL-6、IL-8水平与AECOPD患者临床预后有关(P<0.05)。绘制受试者工作特征曲线结果显示,血清IL-6、IL-8及联合预测AECOPD患者临床预后不良的曲线下面积(AUC)均≥0.7,均有一定的预测价值。结论血清IL-6、IL-8水平高与AECOPD患者临床预后不良有关,且联合检测血清IL-6、IL-8水平可用于预测AECOPD患者不良临床预后风险。
Objective To investigate the correlation of levels of serum interleukin-6(IL-6)and interleukin-8(IL-8)with the clinical prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and provide a basis for predicting the prognosis of patients.Methods The prospective study method was adopted in this study,and 85 AECOPD patients treated in Zhumadian Central Hospital from April 2019 to April 2020 were included as the study subjects.The levels of serum IL-6 and IL-8 were examined before treatment,and then the patients were treated with systematic comprehensive treatment.At the same time,24 months of follow-up were carried out.The patient’s death or follow-up deadline was the end point of observation,and the survival of the patients was counted.The baseline data questionnaire was designed to collect and record the data needed for the study.Possible factors were allocated into Cox regression analysis to selective analyze the correlation of levels of serum IL-6 and IL-8 with clinical prognosis of AECOPD patients.Results During the observation period,21 of 85 AECOPD patients died,accounting for 24.71%(21/85).Levels of serum IL-6 and IL-8 in patients with poor prognosis were significantly higher than those in patients with good prognosis,with a statistical significant difference(P<0.05).There was no statistical significant difference in general baseline data between patients with poor prognosis and patients with good prognosis(allP>0.05).Cox regression analysis showed that levels of serum IL-6 and IL-8 were related to the clinical prognosis of AECOPD patients(P<0.05).Results of receiver operating characteristic curve showed that the area under the curve(AUC)of serum IL-6,IL-8 and and combination of them in predicting poor prognosis of AECOPD patients were≥0.7,which had certain predictive value.Conclusions High levels of serum IL-6 and IL-8 are associated with poor clinical prognosis in AECOPD patients,and the combined detection of serum IL-6 and IL-8 can be used to predict the risk of
作者
李玲
赵兵
Li Ling;Zhao Bing(Department of Respiratory and Critical Care Medicine,Zhumadian Central Hospital,Zhumadian 463000,China)
出处
《中国实用医刊》
2023年第16期48-51,共4页
Chinese Journal of Practical Medicine
