摘要
目的:探讨超声造影定量参数在Luminal型乳腺癌诊断中的价值,分析Luminal型乳腺癌患者超声造影定量参数与其雄激素受体(AR)及肿瘤增殖细胞相关抗原Ki-67的相关性。方法:选取医院收治的90例Luminal型乳腺癌患者,并根据病理及免疫组化检测结果将其分为LuminalA型组(32例)和LuminalB型组(58例),比较两组患者超声造影表现差异及定量参数,同时比较定量参数与Ki-67及AR表达水平的相关性。结果:两组患者的超声造影增强强度、灌注缺损、增强边界及穿入血流表现比较,差异均有统计学意义(x^(2)=5.204,x^(2)=11.880,x^(2)=6.556,x^(2)=7.249;P<0.05)。LuminalB型组患者与LuminalA型组相比,病灶区域血流灌注的峰值强度(PI)上升,达峰时间(TTP)及平均渡越时间(TOF)下降,差异均有统计学意义(t=8.084,t=8.639,t=7.945;P<0.05)。LuminalA型组患者Ki-67及AR阳性检出率低于LuminalB型组,差异有统计学意义(x^(2)=4.224,x^(2)=4.262;P<0.05)。90例Luminal型乳腺癌患者PI与Ki-67和AR表达水平均呈正相关(r=0.159,r=0.657;P<0.05);TTP、TOF与Ki-67和AR表达水平均呈负相关(r=-0.537,r=-0.407;r=-0.503,r=-0.023;P<0.05)。结论:超声造影定量参数对Luminal型乳腺癌的临床诊断价值较高,并与AR、Ki-67具有一定的相关性,可用于对Luminal型乳腺癌状况变化的诊断评估。
Objective:To analyze the value of the quantitative parameters of contrast-enhanced ultrasound(CEUS)in diagnosing Luminal breast cancer,and analyze the correlations between that and the expression levels of androgen receptor(AR)and the proliferation associated antigen of tumor cell(Ki-67)of patients with Luminal type of breast cancer.Methods:A total of 90 patients with Luminal type of breast cancer who admitted to hospital were selected as the study subjects,and they were divided into Luminal A type group(32 cases)and Luminal B type group(58 cases)according to the pathological and immunohistochemical detection results.The differences of CEUS appearance and quantitative parameters between two groups were compared,and the correlations between quantitative parameters and expression levels of Ki-67 and AR were compared at the same time.Results:The differences of CEUS enhanced intensity,and the appearances of perfusion defects,enhanced boundaries and penetrating blood flow between two groups were significant(x^(2)=5.204,x^(2)=11.880,x^(2)=6.556,x^(2)=7.249,P<0.05),repsectively.Compared with patients of Luminal A type group,the peak intensity(PI)of Luminal B group significantly increased,and the time to peak(TTP)and mean transit time(TOF)significantly decreased,with significant differences(t=8.084,t=8.639,t=7.945,P<0.05),respectively.The positive detection rates of Ki-67 and AR of patients in Luminal A type group were significantly lower than those of Luminal B type group(x^(2)=4.224,x^(2)=4.262,P<0.05),respectively.The PI was positively correlated to the expression levels of Ki-67 and AR in 90 Luminal type of breast cancer(r=0.159,r=0.657,P<0.05),respectively.The TTP and TOF were negatively correlated to the expression levels of Ki-67 and AR,with significant differences(r=0.537,r=-0.407,r=-0.503,r=-0.023,P<0.05),respectively.Conclusion:The CEUS quantitative parameter has higher clinically diagnostic value for Luminal type of breast cancer,which has a certain relationship with AR and Ki-67,and it can be used in the diag
作者
仓庆
张婷
叶新华
CANG Qing;ZHANG Ting;YE Xin-hua(Department of Ultrasound Medicine,The First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,China)
出处
《中国医学装备》
2023年第10期93-97,共5页
China Medical Equipment
基金
江苏省卫生健康委科研项目(2021014)“多模态成像评价智能纳米平台介导三阴性乳腺癌诊疗一体化的研究”。
关键词
超声造影定量参数
Luminal型乳腺癌
雄激素受体
增殖细胞相关抗原Ki-67
Quantitative parameters of contrast-enhanced ultrasound(CEUS)
Luminal type of breast cancer
Androgen receptor(AR)
Proliferation associated antigen of tumor cell(Ki-67)
