摘要
目的:利用 18F-MK6240 PET显像研究阿尔茨海默病(AD)中tau蛋白沉积模式及其与认知的相关性。 方法:从上海门诊及社区纳入2021年8月至2022年2月间共55岁以上的老年人46例[男16例、女30例,年龄(68.9±7.7)岁],对入组受试者行脑MRI、β淀粉样蛋白(Aβ)PET显像、tau蛋白PET显像和神经心理学量表测试,根据2018年美国国立老化研究所与阿尔茨海默协会(NIA-AA)的诊断标准,将受试者分为AD组(16例)与认知正常(NC)组(30例)。利用MRI图像对 18F-MK6240 PET图像进行预处理后进行定量分析,研究AD中tau蛋白的沉积特征,选择内嗅皮质、海马、海马旁回、杏仁核、岛叶、额叶、楔前叶、枕叶、丘脑、壳核等脑区,以小脑作为参考区,计算tau蛋白沉积 18F-MK6240的SUV比值(SUVR)。采用两独立样本 t检验比较各脑区间tau蛋白沉积的差异,采用Pearson相关分析各脑区SUVR与简易精神状态检查量表(MMSE)评分、蒙特利尔认知评估基础量表(MoCA-B)评分的相关性。 结果:18F-MK6240 PET显像示AD组的tau蛋白广泛沉积于额叶、颞叶、顶叶等脑区。AD组在各脑区间的SUVR均较NC组高( t值:3.37~9.61,均 P<0.05)。各脑区的SUVR与MMSE评分( r值:-0.735~-0.350,均 P<0.05)、MoCA-B评分( r值:-0.723~-0.367,均 P<0.05)均呈负相关。 结论:18F-MK6240 PET能显示AD患者脑内tau蛋白分布特征,且tau蛋白的沉积与认知功能相关。
ObjectiveTo investigate the tau deposition pattern in Alzheimer′s disease(AD)and its correlation with cognition by 18F-MK6240 PET imaging.MethodsFrom August 2021 to February 2022,46 elderly people over 55 years old(16 males,30 females;age(68.9±7.7)years)were included from outpatient and community in Shanghai.Structural brain MRI,β-amyloid(Aβ)PET imaging,tau-PET imaging and comprehensive neuropsychological tests batteries were conducted.The subjects were divided into AD group(n=16)and normal cognition(NC)group(n=30)according to the 2018 National Institute on aging and Alzheimer′s Association(NIA-AA)diagnostic criteria.Quantitative analysis was conducted to investigate the tau deposition pattern in AD after preprocessing 18F-MK6240 PET images with MRI images.SUV ratio(SUVR)of brain regions such as entorhinal cortex,hippocampus,parahippocampal gyrus,amygdala,insular lobe,frontal lobe,precuneus,occipital lobe,thalamus and putamen were analyzed,with cerebellum as reference region.The differences of tau deposition in brain regions between AD and NC groups were analyzed by independent-sample t test.The associations between SUVR and Mini-Mental State Examination(MMSE)score and Montreal Cognitive Assessment-Basic(MoCA-B)score were analyzed by Pearson correlation analysis.ResultsAD displayed a significant tau deposition in frontal lobes,temporal lobes and parietal lobes compared with NC.SUVR of brain regions in AD group were higher than those in NC group(t values:3.37-9.61,all P<0.05).SUVR in brain regions were negatively correlated with MMSE score(r values:from-0.735 to-0.350,all P<0.05)and MoCA-B score(r values:from-0.723 to-0.367,all P<0.05).Conclusion18F-MK6240 PET can demonstrate the tau deposition in the brain of AD patients,and the tau deposition is related to cognitive function.
作者
王惟一
王莹
王梦洁
王杰
李骏鹏
姜东朗
肖见飞
任树华
黄琪
何坤
管一晖
郭起浩
李彬寅
谢芳
Wang Weiyi;Wang Ying;Wang Mengjie;Wang Jie;Li Junpeng;Jiang Donglang;Xiao Jianfei;Ren Shuhu;a Huang Qi;He Kun;Guan Yihui;Guo Qihao;Li Binyin;Xie Fang(PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China;Department of Gerontology,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China;Department of Neurology&Institute of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2023年第10期583-587,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
国家自然科学基金(81801752,81571345,82171473)
科技创新2030重大项目(2022ZD0213800)。
