摘要
目的探讨抗炎饮食与心力衰竭(HF)及其亚型的相关性。方法入选2021年10月~2022年9月山西医科大学第二医院心内科住院患者278例,根据是否患有HF,分为HF组(n=204)和非HF组(n=74)。HF组患者根据左室射血分数(LVEF)分为射血分数保留型心力衰竭(HFpEF)组(n=77)、射血分数降低型心力衰竭(HFrEF)组(n=70)和射血分数中间值心力衰竭(HFmrEF)组(n=57)。通过电子病历系统收集患者的一般临床资料、生化指标、营养风险评分(NRS-2002)。采用经验证的半定量食物频度问卷(FFQ)收集患者入院前的饮食信息,并根据《中国居民膳食指南科学研究报告(2021)》计算抗炎饮食评分。超声心动图测量左房内径(LAD)、左室舒张末期内径(LVEDd)与LVEF。结果心力衰竭及其亚型HFrEF组、HFmrEF组、HFpEF组患者抗炎饮食评分均低于非HF组患者(均P<0.01),HFrEF组、HFmrEF组、HFpEF组患者组间差异无统计学意义。HF组地高辛、髓过氧化物酶数据高于非HF组(均P<0.05),CCB低于非HF组(P<0.05),螺内酯、利尿药、RDW、NLR、ST2、BNP、K、LAD、LVEDd、NRS-2002高于非HF组(均P<0.01),BMI、合并高血压、受教育程度大专及以上、TC、TG、HDLC、LDL-C、LVEF、血浆白蛋白低于非HF组(均P<0.01)。Spearman相关分析显示抗炎饮食评分与HF发生呈负相关(P<0.01),经BMI、药物治疗、合并高血压、受教育程度、RDW、NLR、ST2、BNP、K、TC、TG、HDL-C、LDLC、LAD、LVEDd、LVEF、血浆白蛋白及NRS-2002校正后,这种相关性依然存在。二元Logistic回归分析显示,低水平抗炎饮食评分为HF的影响因素(P<0.05)。绘制受试者工作特征(ROC)曲线分析结果显示,抗炎饮食评分预测HF发生的曲线下面积(AUC)为0.773(95%CI:0.707~0.839,P<0.01),最佳临界值为8.5分,灵敏度与特异度分别为72.5%和73.0%。结论低水平抗炎饮食评分是HF的危险因素之一,可据此对患者进行健康饮食管理。
AIM To explore the correlation between anti-inflammatory diet and different types of heart failure(HF).MEHTODS From October 2021 to September 2022,278 hospitalized patients in the Department of Cardiology of the Second Hospital of Shanxi Medical University were divided into HF group(n=204)and non HF group(n=74)based on whether they had HF.Patients in the HF group were divided into ejection fraction retention heart failure(HFpEF)group(n=77),ejection fraction reduction heart failure(HFrEF)group(n=70),and ejection fraction median heart failure(HFmrEF)group(n=57)based on left ventricular ejection fraction(LVEF).The general clinical data,biochemical indicators,and nutritional risk scores of patients were collected through the electronic medical record system(NRS-2002).The validated semi quantitative food frequency questionnaire(FFQ)was used to collect dietary information of patients before admission,and the anti-inflammatory dietary score was calculated based on the“Scientific Research Report on Chinese Dietary Guidelines(2021)”.Left atrial diameter(LAD),left ventricular end diastolic diameter(LVEDd),and LVEF were measured by echocardiography.RESULTS The anti-inflammatory dietary scores of patients with heart failure and its subtypes in the HFrEF group,HFmrEF group,and HFpEF group were lower than those in the non HF group(all P<0.01).There was no statistically significant difference between the HFrEF group,HFmrEF group,and HFpEF group.The data of digoxin and myeloperoxidase in the HF group were higher than those in the non HF group(all P<0.05),and the CCB was lower than those in the non HF group(P<0.05).Spironolactone,diuretics,RDW,NLR,ST2,BNP,K,LAD,LVEDd,and NRS-2002 were higher than those in the non HF group(all P<0.01).BMI,hypertension,college education or above,TC,TG,HDL-C,LDL-C,LVEF,and plasma albumin were lower than those in the non HF group(all P<0.01).Spearman correlation analysis showed a negative correlation between anti-inflammatory dietary scores and the occurrence of HF(P<0.01).After adjustment for BM
作者
李静
王彩
雷雨
杨成梅
张萌
张洳锋
李彦红
LI Jing;WANG Cai;LEI Yu;YANG Cheng-mei;ZHANG Meng;ZHANG Ru-feng;LI Yan-hong(Shanxi Medical University Graduate School,Taiyuan 030000,Shanxi,China;Department of Cardiology,Second Hospital,Shanxi Medical University,Taiyuan 030000,Shanxi,China)
出处
《心脏杂志》
CAS
2023年第5期563-569,共7页
Chinese Heart Journal
基金
山西省科技厅自然科学研究项目(20210302123282)。
关键词
心力衰竭
抗炎饮食评分
相关性
影响因素
HF
anti-inflammatory diet score
correlation
influential factor
