摘要
目的探究甲羟孕酮联合抗生素治疗子宫内膜炎临床疗效及对患者炎症因子的影响。方法选取2020年4月至2021年3月九江市妇幼保健院接收的86例子宫内膜炎患者作为研究对象,按照抽签法分为参照组与联合组,各43例。参照组予以抗生素治疗,联合组予以甲羟孕酮联合抗生素治疗,比较两组治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶(MMP-9)]水平、临床症状消除时间及临床疗效。结果治疗前,两组TNF-α和MMP-9水平比较差异无统计学意义;治疗后,两组TNF-α和MMP-9水平均低于治疗前,且联合组低于参照组,差异有统计学意义(P<0.05)。联合组盆腔坠痛、小腹胀痛、阴道出血和白带增多症状消除时间均短于参照组,差异有统计学意义(P<0.05)。联合组治疗总有效率为97.67%,高于参照组的81.40%,差异有统计学意义(P<0.05)。结论甲羟孕酮联合抗生素治疗子宫内膜炎患者效果确切,有利于改善其炎症因子水平,促进临床症状消失,值得临床推广应用。
Objective To explore the clinical efficacy of medroxyprogesterone combined with antibiotics in the treatment of endometritis and its influence on inflammatory factors in patients.Methods A total of 86 patients with endometritis who were admitted to Jiujiang Maternal and Child Health Hospital received from April 2020 to March 2021 were selected as the study subjects,and they were divided into the reference group and the combined group by the drawing lots,with 43 cases in each group.The reference group was treated with antibiotics,and the combined group was treated with medroxyprogesterone combined with antibiotics.The levels of inflammatory factors(tumor necrosis factor-α[TNF-α]and matrix metalloproteinase[MMP-9])before and after treatment,the time to resolve clinical symptoms and the clinical efficacy between the two groups were compared.Results Before treatment,there was no significant difference in TNF-αand MMP-9 levels between the two groups;after treatment,the levels of TNF-αand MMP-9 of the two groups were lower than before treatment,and the combined group were lower than the reference group,and the difference was statistically significant(P<0.05).The elimination time of clinical symptoms such as pelvic pain,lower abdominal pain,vaginal bleeding and increased leucorrhea in the combined group was shorter than that in the reference group,and the differences were statistically significant(P<0.05).The total effective rate in the combined group was 97.67%,which was higher than 81.40%in the reference group,and the difference was statistically significant(P<0.05).Conclusion Medroxyprogesterone combined with antibiotics is effective in the treatment of patients with endometritis,which is conducive to improving the level of inflammatory factors and promoting the disappearance of clinical symptoms,and is worthy of clinical promotion and application.
作者
熊露露
胡婧
曹玲
章超
XIONG Lulu;HU Jing;CAO Ling;ZHANG Chao(Department of Family Planning,Jiujiang Maternal and Child Health Care Hospital,Jiujiang,Jiangxi,332000,China;Department of Pharmaceutical,Jiujiang First People's Hospital,Jiujiang,Jiangxi,332000,China)
出处
《当代医学》
2023年第23期91-93,共3页
Contemporary Medicine
关键词
甲羟孕酮
抗生素
子宫内膜炎
临床疗效
炎症因子
Medroxyprogesterone
Antibiotic
Endometritis
Clinical efficacy
Inflammatory factor
