摘要
目的 观察加味补阳还五汤治疗缺血性中风(气虚血瘀证)的临床疗效并探讨其作用机制。方法 100例患者按随机数字表法分为试验组与对照组各50例。对照组给予常规治疗。试验组在对照组常规治疗基础上加服加味补阳还五汤。两组疗程均为2周。于治疗前、治疗后14 d分别根据神经功能缺损量表(NIHSS)评分、日常生活活动能力量表(ADL)评分、改良金兰量表(MRS)评分、中医证候疗效评价两组的临床疗效。在治疗前、治疗后14 d检查患者肝功、肾功、大便隐血,观察患者有无恶心呕吐、腹泻的不良反应,从而评估其安全性。结果 试验组总有效率为96.00%,高于对照组的78.00%(P <0.05)。两组治疗后中医证候评分与治疗前比较均降低,且观察组中医证候各项评分均低于对照组(均P <0.05)。两组治疗后NIHSS、MRS评分与治疗前比较均降低,ADL量表评分则均升高,且观察组各项指标评分情况均优于对照组(均P <0.05)。两组患者治疗期间均未出现明显不良反应,患者肝功、肾功、大便隐血均未见明显变化,安全性良好。结论 加味补阳还五汤联合西医常规治疗缺血性中风(气虚血瘀证),可提高临床总有效率,促进患者自理能力和神经功能恢复,降低致残率,改善预后,提高患者生活质量。
Objective:To observe the clinical efficacy of Modified Buyang Huanwu Decoction in the treatment of ischemic stroke(syndrome of blood stasis due to qi deficiency),and to discuss its mechanism of action and safety evaluation.Methods:A total of 100 patients were divided into experimental group and control group with 50 patients in each group according to random number table method.The control group was given conventional treatment.The experimental group was given Modified Buyang Huanwu Decoction on the basis of conventional treatment in the control group.The treatment course of both groups was 2 weeks.The clinical efficacy of Modified Buyang Huanwu Decoction on ischemic stroke(syndrome of blood stasis due to qi deficiency)was evaluated be⁃fore and 14 days after treatment according to the Neurological Deficit Scale(NIHSS)score,the ability of daily liv⁃ing(ADL scale)score and the observation index of TCM syndrome efficacy.Liver function,kidney function and fe⁃cal occult blood of patients were examined before treatment and 14 days after treatment,and adverse reactions of nausea,vomiting and diarrhea were observed,so as to evaluate their safety.Results:The total effective rate of the experimental group was 96.00%,which was higher than 78.00%of the control group(P<0.05).The scores of TCM syndrome(hemiplegia,crooked mouth and eyes,stiff tongue and dysphasia,dizziness)in both groups were lower af⁃ter treatment than before,and the scores of TCM syndrome in the observation group were lower than those in the control group(all P<0.05).The scores of NIHSS and MRS in both groups were decreased after treatment,while the scores of ADL scale were increased,and the scores in the observation group were all better than those in the con⁃trol group(all P<0.05).No obvious adverse reactions were observed in the two groups during treatment,and no significant changes were observed in liver function,kidney function and fecal occult blood,indicating good safety.Conclusion:Modified Buyang Huanwu Decoction combined with conventional w
作者
桂平
程小凤
Gui Ping;Cheng Xiaofeng(Chongqing Jiangjin District Hospital of Traditional Chinese Medicine,Chongqing 402260,China.)
出处
《中国中医急症》
2023年第10期1798-1801,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
重庆市江津区科技计划项目(Y2021075)。
关键词
缺血性中风
加味补阳还五汤
气虚血瘀
疗效
安全性评估
Ischemic stroke
Modified Buyang Huanwu Decoction
Syndrome of blood stasis due to qi deficien⁃cy
Efficacy
Safety evaluation
