摘要
目的:探讨双氯芬酸钠缓释片、甲钴胺片联合普瑞巴林胶囊治疗带状疱疹后遗神经痛的效果。方法:选取2020年3月—2023年3月吴川市第二人民医院收治的带状疱疹后遗神经痛患者51例作为研究对象,根据就诊序号单双数分为参照组(26例,给予双氯芬酸钠缓释片联合甲钴胺治疗)与研究组(25例,在参照组基础上给予普瑞巴林胶囊治疗)。比较两组患者治疗前后疼痛介质水平、疼痛症状评分及不良反应发生率。结果:治疗后,研究组血清神经肽Y、P物质、神经激肽-1水平低于参照组,β-内啡肽水平高于参照组,差异有统计学意义(P<0.05);治疗后,两组简化McGill疼痛量表评分低于治疗前,研究组低于参照组,差异有统计学意义(P<0.001);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双氯芬酸钠缓释片、甲钴胺片联合普瑞巴林胶囊治疗带状疱疹后遗神经痛的效果显著,可调节患者疼痛介质水平,缓解疼痛症状,不良反应少,可行性和安全性较高。
Objective:To investigate the effect of diclofenac sodium extended-release tablets,mecobalamin combined with pregabalin capsules in the treatment of postherpetic neuralgia.Methods:Fifty-one patients with postherpetic neuralgia admitted to Wuchuan Second People's Hospital from March 2020 to March 2023 were selected as study subjects.They were divided into the reference group(26 cases,given diclofenac sodium extended-release tablets combined with mecobalamin treatment)and the study group(25 cases,given pregabalin capsules on the basis of the reference group)according to the single and double numbers of the serial number of the consultation.Pain mediator levels,pain symptom scores and the incidence of adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the levels of serum neuropeptide Y,substance P and neurokinin-1 in the study group were lower than those in the reference group,and the levels ofβ-endorphin were higher than those in the reference group,with statistically significant differences(P<0.05);After treatment,the simplified McGill Pain Scale scores of the two groups were lower than those before treatment,and the study group was lower than the reference group,and the difference was statistically significant(P<0.001);Comparison of the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Diclofenac sodium extended-release tablets and mecobalamin combined with pregabalin capsules are effective in the treatment of postherpetic neuralgia,which can regulate the level of pain mediators,alleviate the symptoms of pain,and have fewer adverse effects,with higher feasibility and safety.
作者
吴倩
Wu Qian(Department of General Medicine,Wuchuan Second People's Hospital,Zhanjiang 524500,Guangdong Province,China)
出处
《中外医药研究》
2023年第15期9-11,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
