摘要
脑静脉窦血栓形成(cerebral venous sinus thrombosis,CVST)是卒中的特殊亚型,占所有脑卒中的0.5%~1%,好发于青壮年和女性。其病理机制复杂,诊断困难,漏诊及误诊率高,重症病死率高达30%,是神经科的疑难病。除血栓形成外,还伴有不同的CVST相关实质损伤,包括水肿、缺血性卒中和脑内出血。为了进一步探索CVST的病理演变规律及分子病理特征,需要建立适宜的CVST动物模型,以研究CVST血栓形成、脑组织损伤等分子病理机制以及相关防治方案。本篇综述主要概述了现有的CVST实验动物模型,重点分析了每一种模型的优势、局限性和当前相关研究的应用,以期为CVST的基础研究提供借鉴。
Cerebral venous sinus thrombosis(CVST)is a special subtype for 0.5%-1%of all strokes,and it tends to occur in young adults and women.It is a difficult disease in neurology because of its complex pathology.The clinical diagnosis is difficult,with high rate of missed diagnosis and misdiagnosis,and severe mortality rate up to 30%.Beyond thrombosis,different CVST-related parenchymal injuries may occur and include edema,ischemic strokes,and intra-cerebral hemorrhage.There are many uncontrollable factors involved during CVST development.In order to further explore the pathological evolution and molecular pathological characteristics of CVST,it is necessary to establish a suitable animal model of CVST to study the molecular pathological mechanisms of CVST thrombosis,brain tissue damage and related prevention and treatment programs.Importantly,animal models are useful to study new therapeutic approaches.In this review,we provide a mainly overview of CVST experimental animal models,focusing on their strengths,limits,and applications for relevant studies.
作者
马薇
周一帆
姜慧敏
卫慧敏
周陈
吉训明
Ma Wei;Zhou Yifan;Jiang Huimin;Wei Huimin;Zhou Chen;Ji Xunming(Beijing Institute of Brain Disorders of Capital Medical University,Beijing 100069,China;Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《首都医科大学学报》
CAS
北大核心
2023年第5期704-714,共11页
Journal of Capital Medical University
基金
北京市教育委员会科技创新服务能力建设项目(11000023T000002157177)。
关键词
脑血管病
脑卒中
脑静脉窦血栓形成
动物模型
静脉性卒中
cerebrovascular disease
stroke
cerebral venous sinus thrombosis
animal models
venous stroke
