摘要
目的探究大五人格特质、童年期创伤、生活事件等因素对抑郁症患者自杀意念的影响。方法采用病例对照研究设计,纳入127例有自杀意念(有自杀意念组)和44例无自杀意念(无自杀意念组)的首发未服药抑郁症患者及185名健康对照(对照组)。采用大五人格量表简化版(neuroticism extraversion openness five-factor inventory,NEO-FFI)、童年期创伤问卷-简版(childhood trauma questionnaire-short form,CTQ-SF)和生活事件单位(life event unit,LEU)分别评估被试的人格特质、童年期创伤经历和生活事件。结果NEO-FFI中,有、无自杀意念组的神经质得分高于对照组(42.87±8.04 vs.37.98±8.42 vs.30.16±6.25),外向性(31.02±6.32 vs.34.11±6.83 vs.40.29±5.37)、宜人性(38.60±5.92 vs.40.36±6.49 vs.44.79±4.68)和责任感(38.98±7.16 vs.40.89±6.66 vs.44.09±5.66)得分低于对照组(P<0.01);此外,有自杀意念组的开放性得分低于对照组(33.01±5.07 vs.34.62±4.41,P<0.01);有自杀意念组的神经质得分高于无自杀意念组(P<0.01),外向性得分低于无自杀意念组(P<0.01)。CTQ-SF中,有自杀意念组的情感虐待(7.94±3.37 vs.6.36±1.94)、躯体虐待(6.31±2.23 vs.5.75±1.84)、性虐待(5.69±1.25 vs.5.38±1.33)、情感忽略(12.10±5.22 vs.8.81±3.87)、躯体忽略(9.09±3.72 vs.7.52±2.58)得分和CTQ-SF总分(41.13±11.78 vs.33.82±8.60)均高于对照组(P<0.05);无自杀意念组的情感忽略得分(11.11±5.17 vs.8.81±3.87)和CTQ-SF总分(37.66±9.95 vs.33.82±8.60)高于对照组(P<0.01);有自杀意念组的CTQ-SF总分高于无自杀意念组(P<0.05)。LEU中,有、无自杀意念组LEU总分高于对照组(69.65±5.27 vs.70.34±5.50 vs.66.64±1.82,P<0.05)。logistic回归分析显示,抑郁症患者出现自杀意念与HAMD-17总分(OR=1.399,P<0.001)、神经质人格(OR=1.096,P=0.042)、躯体虐待(OR=1.523,P=0.012)有关联。结论严重的抑郁症状、高神经质和童年期躯体虐待经历可能是抑郁症患者出现自杀意念的危险因�
Objective To investigate the effects of the Big Five personality traits,childhood trauma and life events on suicidal ideation(SI)in patients with major depressive disorder(MDD).Methods One hundred twenty-seven first-episode unmedicated MDD patients with SI,44 first-episode unmedicated MDD patients without SI and 185 healthy controls were included in this study.The neuroticism extraversion openness five-factor inventory(NEO-FFI),the childhood trauma questionnaire-short form(CTQSF)and the life event unit(LEU)were used to assess personality traits,childhood trauma experiences and life events,respectively.Results In the NEO-FFI,neuroticism scores were higher in the group with and without SI than in the control group(42.87±8.04 vs.37.98±8.42 vs.30.16±6.25),and extraversion(31.02±6.32 vs.34.11±6.83 vs.40.29±5.37),agreeableness(38.60±5.92 vs.40.36±6.49 vs.44.79±4.68)and conscientiousness(38.98±7.16 vs.40.89±6.66 vs.44.09±5.66)scores were lower than in the control group(P<0.01).In addition,openness scores were lower in the group with SI than in the control group(33.01±5.07 vs.34.62±4.41,P<0.01).Neuroticism scores were higher and extraversion scores were lower in the group with SI than in the group without SI(P<0.01).In the CTQ-SF,emotional abuse(7.94±3.37 vs.6.36±1.94),physical abuse(6.31±2.23 vs.5.75±1.84),sexual abuse(5.69±1.25 vs.5.38±1.33),emotional neglect(12.10±5.22 vs.8.81±3.87),physical neglect(9.09±3.72 vs.7.52±2.58)and total CTQ-SF scores(41.13±11.78 vs.33.82±8.60)were higher in the group with SI than in the control group(P<0.05).Emotional neglect(11.11±5.17 vs.8.81±3.87)and total CTQ-SF(37.66±9.95 vs.33.82±8.60)scores were higher in the group without SI than in the control group(P<0.01).And total CTQ-SF scores were higher in the group with SI than in the group without SI(P<0.05).In LEU,total LEU score was higher in the group with and without SI than in the control group(P<0.05).Logistic regression analysis showed that the presence of SI in MDD patients was associated with total HA
作者
储召松
王欣
程宇琪
许秀峰
张芳芳
沈宗霖
CHU Zhaosong;WANG Xin;CHENG Yuqi;XU Xiufeng;ZHANG Fangfang;SHEN Zonglin(Department of Psy-chiatry,the First Affiliated Hospital of Kunming Medical University,Yunnan Province Clinical Research Center for Mental Health,Kunming 650032,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2023年第7期396-401,共6页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金(编号:82260277)
国家自然科学基金(编号:81660237)
云南省精神心理疾病临床医学研究中心(编号:0105679005)
云南省高层次卫生计生技术人才培养经费(编号:H-2018090)
省基础研究计划(昆医联合专项)(编号:2019FE001(-144))。
关键词
抑郁症
自杀意念
人格
神经质
身体虐待
症状评估
危险因素
Major depressive disorder
Suicidal ideation
Personality Neuroticism
Physical abuse
Symptom assessment
Risk factors
