摘要
胰腺神经内分泌肿瘤(pNET)是一种较为罕见的、具有高度异质性的内分泌肿瘤,占胰腺恶性肿瘤的约9.9%。然而由于其早期症状隐匿,多数患者临床就诊时已出现远处转移。因此,早发现、早干预尤为重要。目前,手术切除依然是治愈pNET的唯一方式,传统治疗方式如放、化疗虽然可以有效杀伤肿瘤细胞提高患者生存期,但是其治疗效果始终不如人意。近年来,随着一些新治疗方式如靶向治疗、免疫治疗、表观遗传药物治疗等手段的出现,让许多无法手术且对传统治疗方法不敏感的患者从中获益。笔者围绕pNET近年诊断、非手术治疗方面的研究进展展开综述。
Pancreatic neuroendocrine tumors(pNETs)are a relatively rare and highly heterogeneous type of neuroendocrine tumors,accounting for approximately 9.9%of malignant pancreatic tumors.However,due to their subtle early symptoms,most patients are diagnosed when distant metastases have already occurred.Therefore,early detection and intervention are particularly important.Currently,surgical resection remains the only curative option for pNETs.Although traditional treatment modalities such as radiation and chemotherapy can effectively kill tumor cells and improve patient survival,their treatment outcomes have always been unsatisfactory.In recent years,the emergence of new treatment modalities such as targeted therapy,immunotherapy,epigenetic drugs,and other approaches has benefited many patients who are not eligible for surgery and are insensitive to traditional treatment methods.Here,the authors discuss recent advances in the diagnosis and non-surgical treatment of pNETs.
作者
张梓桐
詹峰
ZHANG Zitong;ZHAN Feng(Nanjing Medical University Wuxi Medical Center Yixing Branch Center,Yixing,Jiangsu 214200,China;Nanjing Medical University First School of Clinical Medicine,Nanjing 210000,China;Department of Hepatobiliary and Pancreatic Surgery,Yixing People's Hospital,Yixing,Jiangsu 214200,China)
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2023年第9期1387-1395,共9页
China Journal of General Surgery
基金
江苏省无锡市卫健委科研基金资助项目(Q202027)
江苏省宜兴市卫健委面上基金资助项目(2022-14)。
