摘要
背景我国中老年人群代谢综合征(MS)患病率逐年攀升,血清尿酸(SUA)/高密度脂蛋白胆固醇(HDL-C)比值(UHR)与多种代谢性疾病密切相关,但在中老年人群中,关于UHR与MS关联的研究较少。目的探讨中国中老年人群UHR与MS之间的相关性,并评估UHR对MS的预测价值。方法本研究采用2015年中国健康与养老追踪调查(CHARLS)公开数据,纳入9233名研究对象。收集研究对象一般资料、体格检查指标和血生化检查指标。计算研究对象UHR。依据是否患有MS将研究对象分为非MS组(n=7006)与MS组(n=2227),同时按UHR四分位数水平将研究对象分为Q1组(UHR≤7.32%,n=2308)、Q2组(7.32%12.20%,n=2308)。采用Pearson相关性分析探究UHR与代谢指标的相关性;采用多因素Logistic回归分析探讨UHR与MS的关系。分别绘制总体和不同性别研究对象UHR预测MS发生风险的受试者工作特征(ROC)曲线并计算ROC曲线下面积(AUC)。结果研究对象平均年龄(60.3±9.6)岁,MS组女性比例、年龄、城镇比例、高血压史比例、糖尿病史比例、血脂异常史比例、服用降脂药比例、糖化血红蛋白、C反应蛋白、三酰甘油(TG)、总胆固醇(TC)、空腹血糖(FPG)、SUA、收缩压(SBP)、舒张压(DBP)、BMI、腰围(WC)、UHR高于非MS组,HDL-C、低密度脂蛋白胆固醇(LDL-C)、估算的肾小球滤过率(eGFR)低于非MS组,两组受教育程度、吸烟情况、饮酒情况比较,差异有统计学意义(P<0.05)。随着UHR水平的上升,Q1~Q4组MS、中心性肥胖、高血糖、高血压、高TG血症、低HDL-C血症检出率呈上升趋势(P_(趋势)<0.01);Q1~Q4组BMI、WC、SBP、DBP、TG、HDL-C、LDL-C、TC、FPG、eGFR、C反应蛋白水平比较,差异均有统计学意义(P<0.01)。Pearson相关性分析结果显示,UHR与TG、FPG、DBP、SBP、BMI、WC均呈正相关(P<0.01),与HDL-C呈负相关(P<0.01)。按性别分层后,男性、女性UHR与TG、FPG、DBP、SBP、BMI、WC均呈正相关(P<0.01),与HDL-C呈负相关(P
Background The prevalence of metabolic syndrome(MS)among the middle-aged and elderly population in China increases with age,serum uric acid to high density lipoprotein cholesterol ratio(UHR)is closely associated with various metabolic diseases,however,there are few studies on the relationship between UHR and MS in middle-aged and elderly people.Objective To explore the correlation between UHR and MS in middle-aged and elderly people in China,and evaluate the predictive value of UHR for MS.Methods This study used public data from the 2015 China Health and Retirement Longitudinal Survey(CHARLS)and included 9233 subjects.General data,physical examination indexes and blood biochemical examination indexes were collected from the study subjects and their UHR was calculated.The subjects were divided into the non-MS group(n=7006)and MS group(n=2227)according to whether they had MS.At the same time,the subjects were divided into the Q1 group(UHR≤7.32%,n=2308),Q2 group(7.32%<UHR≤9.45%,n=2307),Q3 Group(9.45%<UHR≤12.20%,n=2310)and Q4 group(UHR>12.20%,n=2308)according to the level of the quartiles of UHR.Pearson correlation analysis was used to explore the correlation between UHR and metabolic indexes.The relationship between UHR and MS was studied by multivariate Logistic regression analysis.The receiver operating characteristic(ROC)curves for the risk of MS predicted by UHR in the overall and by different genders were plotted separately and the areas under the ROC curve(AUC)were calculated.Results The average age of the subjects was(60.3±9.6)years.The proportion of females,age,urban household proportion,history of hypertension,diabetes and dyslipidemia,proportion of taking lipid-lowering drugs,glycated hemoglobin,C-reactive protein,triglyceride(TG),total cholesterol(TC),fasting plasma glucose(FPG),SUA,systolic blood pressure(SBP),diastolic blood pressure(DBP),BMI,waist circumference(WC)and UHR in the MS group were higher than the non-MS group,while HDL-C,low-density lipoprotein cholesterol(LDL-C)and estimated glomeru
作者
吴瑞鹏
彭成
袁丙坤
章梦君
李文源
WU Ruipeng;PENG Cheng;YUAN Bingkun;ZHANG Mengjun;LI Wenyuan(School of Health Services Management,Southern Medical University,Guangzhou 510515,China;School of Public Health,Southern Medical University,Guangzhou 510515,China;Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
出处
《中国全科医学》
北大核心
2024年第3期293-299,共7页
Chinese General Practice
基金
广东省重点领域研发计划(2019B020227004)。
关键词
代谢综合征
尿酸
高密度脂蛋白胆固醇
中国健康与养老追踪调查
中年人
老年人
预测
Metabolic syndrome
Uric acid
High density lipoprotein cholesterol
China Health and Retirement Longitudinal Study
Middle-aged
Aged
Forecasting
