摘要
目的探讨Toll样受体4(TLR4)、正五聚蛋白3(PTX3)、血小板与淋巴细胞比值(PLR)在急性缺血性脑卒中机械取栓术后患者预后中的应用。方法回顾性分析2021年1月至2022年12月安阳市人民医院收治的160例急性缺血性脑卒中患者的病案资料,患者均接受机械取栓术治疗。用改良Rankin量表(mRS)对患者术后1、3个月的预后进行评估,术后1个月mRS≤3分为预后良好,mRS>3分为预后不良;术后3个月mRS≤2分为预后良好,mRS>2分预后不良。比较预后良好组与预后不良组TLR4、PTX3、PLR水平,分析TLR4、PTX3、PLR预测急性缺血性脑卒中机械取栓术后患者预后的价值。结果预后不良组术后1、3个月的mRS评分、TLR4、PTX3、PLR水平高于预后良好组(P<0.05),TLR4、PTX3、PLR联合预测急性缺血性脑卒中机械取栓术后1、3个月预后不良的曲线下面积(AUC)高于单一指标(P<0.05)。结论TLR4、PTX3、PLR在急性缺血性脑卒中机械取栓术后预后不良中呈高表达,对术后的预后预测有一定价值,能反映机体炎症状态及血小板活化情况,为预后预测提供重要参考依据。
Objective To investigate the prognostic effects of toll-like receptor 4(TLR4),pentraxin 3(PTX3)and platelet to lymphocyte ratio(PLR)in patients with acute ischemic stroke after mechanical thrombectomy.Methods Retrospective analysis was performed on the medical record data of 160 patients with acute ischemic stroke admitted to Anyang People’s Hospital from January 2021 to December 2022.All patients received mechanical thrombectomy.Prognosis assessment was performed on patients with modified Rankin scale(mRS)1 and 3 months after surgery.One month after surgery mRS≤3 was classified as good prognosis,mRS>3 was classified as poor prognosis,three months after surgery mRS≤2 was classified as good prognosis,mRS>2 was classified as poor prognosis.The levels of TLR4,PTX3 and PLR were compared between good prognosis group and poor prognosis group,and the application value of TLR4,PTX3 and PLR in prognosis prediction of patients with acute ischemic stroke after mechanical thrombectomy was analyzed.Results The mRS scores,TLR4,PTX3 and PLR levels of the poor prognosis group were higher than those of the good prognosis group 1 month and 3 months after surgery(P<0.05).The area under the curve(AUC)of TLR4,PTX3 and PLR combined predicted poor prognosis 1 and 3 months after mechanical thrombectomy of acute ischemic stroke was higher than that of single index(P<0.05).Conclusion TLR4,PTX3 and PLR are highly expressed in patients with poor prognosis after mechanical thrombectomy of acute ischemic stroke,which has certain application value in postoperative prognosis prediction.They can reflect the inflammatory state and platelet activation of the body,and provide an important reference for prognosis prediction.
作者
许绯
孙科
罗雪
XU Fei;SUN Ke;LUO Xue(Department of Neurology,Anyang People’s Hospital,Anyang 455000,China)
出处
《河南医学研究》
CAS
2023年第19期3521-3526,共6页
Henan Medical Research
